...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Osteoarthritis and cartilage >Focal knee resurfacing and effects of surgical precision on opposing cartilage. A pilot study on 12 sheep
【24h】

Focal knee resurfacing and effects of surgical precision on opposing cartilage. A pilot study on 12 sheep

机译：膝关节表面重铺以及手术精度对相对软骨的影响。十二只绵羊的初步研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Full thickness cartilage lesions (ICRS grade 3-4) and focal lesions of degenerative origin may progress to osteoarthritis (OA). Such focal lesions can be treated by metallic implants. We hypothesized that such treatment results in opposing surface cartilage damage that correlates with implant position (height) relative to the adjacent cartilage surface. This relationship was investigated using a sheep animal model. Methods: Both medial femoral condyles of 12 sheep were operated. The implants, were inserted in the weight-bearing surface at different heights relative to the surrounding cartilage. Euthanasia was performed at 6 or 12 weeks. After retrieval, implant height was analyzed using laser scanning. Damage to the opposing tibial cartilage was evaluated macroscopically and microscopically according to the modified Mankin score. Results: Twenty-two knees were available for evaluation and showed cartilage lesions ranging from severe damage (Mankin stage 11) to almost pristine conditions (Mankin stage 1). There was a strong correlation between implant height and cartilage damage. Standard deviation from the aimed implant height was 0.47 mm. Conclusions: Our results showed significant surgical imprecision and protruding implants imposed severe cartilage damage. We therefore suggest implants should be placed recessed (approx. 0.5 mm) below the surrounding cartilage in this animal model. These results encourage further studies of metallic implants yet the utmost precision regarding position is required.
机译：背景：软骨全厚度病变（ICRS 3-4级）和变性起源的局灶性病变可能发展为骨关节炎（OA）。这种局灶性病变可以通过金属植入物治疗。我们假设这种治疗会导致相对的表面软骨损伤，该损伤与植入物相对于相邻软骨表面的位置（高度）相关。使用绵羊动物模型研究了这种关系。方法：对12只绵羊的内侧股骨con进行手术。将植入物以相对于周围软骨不同的高度插入承重表面。安乐死在第6或12周进行。取回后，使用激光扫描仪分析植入物高度。根据改良的Mankin评分，宏观和微观评估对胫骨软骨的损害。结果：22条膝盖可用于评估，并显示出软骨损伤，范围从严重损害（Mankin 11期）到几乎原始的状况（Mankin 1期）。植入物高度与软骨损伤之间有很强的相关性。与目标植入物高度的标准偏差为0.47 mm。结论：我们的结果表明手术不精确，突出的植入物严重破坏了软骨。因此，在此动物模型中，我们建议将植入物放置在软骨周围下方（约0.5 mm）。这些结果鼓励了对金属植入物的进一步研究，但需要关于位置的最大精度。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号