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首页> 外文期刊>Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA >The effect of growth hormone deficiency on size-corrected bone mineral measures in pre-pubertal children
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The effect of growth hormone deficiency on size-corrected bone mineral measures in pre-pubertal children

机译：生长激素缺乏对青春期前儿童尺寸校正的骨矿物质测量的影响

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Summary Growth hormone deficiency (GHD) in children has been frequently perceived to be a cause of low bone mass accrual. The confounding effects of poor growth limit the interpretation of prior studies of bone health in GHD. We studied size-corrected bone mineral measures in 30 prepubertal GHD children and 75 healthy controls. Our study shows that size-corrected whole-body bone mineral content of GHD children were comparable with controls. Introduction The purpose of this study is to evaluate the effects of GHD on size-corrected bone measures at the lumbar spine (LS) and the whole body (WB). Methods LS bone area (BA), LS bone mineral content (BMC), WB BA, WB BMC, and lean body mass (LBM) were measured in 30 pre-pubertal GHD children and 75 controls by dual-energy X-ray absorptiometry. Multiple linear regressions were used to calculate size-corrected (Sc) LS BASc, LS BMCSc, WB BASc, and WB BMCSc from control subjects using height and age as independent variables. Furthermore, the relationship between muscle and bone was studied by first assessing LBM for height (LBMHt) and then determining WB BMC for LBM (WB BMCLBM). All values were converted to Z-scores and compared with the control. Results At diagnosis, WB BMC Sc Z-score of GHD children was not significantly different from controls. However, mean Z-scores of LS BASc (-0.89±0.84, p0.0001), LS BMCSc (-0.70±1.1, p0.001), WB BASc (-0.65±1.0, p0.006), and LBMHt (-0.66±1.7, p0.01) were significantly reduced, and WB BMCLbm (0.78±1.5, p0.003) was significantly higher in GHD children than controls. Conclusion Size-corrected WB BMC of GHD children were comparable with controls, and bones were normally adapted for muscle mass. Determinants of bone strength which may primarily be affected by GHD are muscle mass, bone size, and geometry rather than bone mass.
机译：小结人们通常认为儿童生长激素缺乏症（GHD）是导致骨质积聚减少的原因。生长不良的混杂影响限制了对GHD骨骼健康先前研究的解释。我们在30名青春期前GHD儿童和75名健康对照中研究了尺寸校正的骨矿物质测量方法。我们的研究表明，经校正的GHD儿童全身骨矿物质含量与对照组相当。引言这项研究的目的是评估GHD对腰椎（LS）和全身（WB）进行尺寸校正的骨测量的影响。方法采用双能X线吸收法测定30名青春期前GHD患儿和75名对照组的LS骨面积（BA），LS骨矿物质含量（BMC），WB BA，WB BMC和瘦体重（LBM）。多元线性回归用于使用身高和年龄作为自变量，从对照对象中计算尺寸校正后的（LS）LS BASc，LS BMCSc，WB BASc和WB BMCSc。此外，通过首先评估LBM的身高（LBMHt），然后确定WB BMC的LBM（WB BMCLBM），研究了肌肉与骨骼之间的关系。将所有值转换为Z分数，并与对照进行比较。结果在诊断时，GHD儿童的WB BMC Sc Z得分与对照组无显着差异。但是，LS BASc（-0.89±0.84，p <0.0001），LS BMCSc（-0.70±1.1，p <0.001），WB BASc（-0.65±1.0，p <0.006）和LBMHt（- GHD儿童的WB BMCLbm（0.78±1.5，p <0.003）显着高于对照组，降低了0.66±1.7，p <0.01）。结论GHD儿童的尺寸校正后的WB BMC与对照组相当，并且骨骼通常适合肌肉质量。可能主要受GHD影响的骨骼强度的决定因素是肌肉质量，骨骼大小和几何形状，而不是骨骼质量。

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