• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA >Protective effect of green tea polyphenols on bone loss in middle-aged female rats.
【24h】

Protective effect of green tea polyphenols on bone loss in middle-aged female rats.

机译：绿茶多酚对中年雌性大鼠骨丢失的保护作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Recent studies have suggested that green tea polyphenols (GTP) are promising agents for preventing bone loss in women. Findings that GTP supplementation resulted in increased urinary GTP concentrations and bone mass via an increase of antioxidant capacity and/or a decrease of oxidative stress damage suggest a significant role of GTP in bone health of women. INTRODUCTION: Recent studies suggested that green tea polyphenols (GTP) are promising agents for preventing bone loss in women. However, the mechanism related to the possible protective role of GTP in bone loss is not well understood. METHODS: This study evaluated bioavailability, mechanisms, bone mass, and safety of GTP in preventing bone loss in middle-aged rats without (sham, SH) and with ovariectomy (OVX). A 16-week study of 2 (SH vs. OVX) x 3 (no GTP, 0.1% GTP, and 0.5% GTP in drinking water) factorial design using 14-month-old female rats (n = 10/group) was performed. An additional 10 rats in baseline group were euthanized at the beginning of study to provide baseline parameters. RESULTS: There was no difference in femur bone mineral density between baseline and the SH+0.5% GTP group. Ovariectomy resulted in lower values for liver glutathione peroxidase activity, serum estradiol, and bone mineral density. GTP supplementation resulted in increased urinary epigallocatechin and epicatechin concentrations, liver glutathione peroxidase activity and femur bone mineral density, decreased urinary 8-hydroxy-2'-deoxyguanosine and urinary calcium levels, but no effect on serum estradiol and blood chemistry levels. CONCLUSION: We conclude that a bone-protective role of GTP may contribute to an increase of antioxidant capacity and/or a decrease of oxidative stress damage.
机译：最近的研究表明，绿茶多酚（GTP）是预防女性骨质流失的有前途的药物。研究发现，补充GTP通过增加抗氧化能力和/或减少氧化应激损伤而导致尿GTP浓度和骨量增加，表明GTP在女性骨骼健康中具有重要作用。简介：最近的研究表明，绿茶多酚（GTP）是预防女性骨质流失的有前途的药物。但是，与GTP可能在骨丢失中起到保护作用有关的机制尚不十分清楚。方法：本研究评估了GTP在预防（假手术，SH）和卵巢切除术（OVX）的中年大鼠预防骨丢失方面的生物利用度，机制，骨量和安全性。使用14个月大的雌性大鼠（n = 10 /组）进行了为期16周的2（SH与OVX）x 3（无GTP，0.1％GTP和0.5％GTP的饮用水）析因设计的研究。 。在研究开始时对基线组的另外10只大鼠实施安乐死以提供基线参数。结果：基线和SH + 0.5％GTP组之间的股骨骨矿物质密度没有差异。卵巢切除术导致肝脏谷胱甘肽过氧化物酶活性，血清雌二醇和骨矿物质密度的值降低。补充GTP导致尿中表没食子儿茶素和表儿茶素的浓度增加，肝谷胱甘肽过氧化物酶活性和股骨骨矿物质密度增加，尿中的8-羟基-2'-脱氧鸟苷和尿钙水平降低，但对血清雌二醇和血液化学水平没有影响。结论：我们得出结论，GTP的骨保护作用可能有助于增加抗氧化能力和/或减少氧化应激损伤。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号