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The effects of Zintona EC (a ginger extract) on symptomatic gonarthritis.

机译：Zintona EC（生姜提取物）对有症状性淋病的作用。

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OBJECTIVE: Evaluation of the effect of a ginger extract (Zintona EC) on patients suffering from gonarthritis. MATERIAL AND METHODS: Twenty-nine patients (6 men and 23 women) with symptomatic gonarthritis (ACR criteria), in the age range 42-85 years, were included after randomization in a double blind, placebo controlled, crossover study of 6 months' duration. The treatment group was given a ginger extract (250 mg of Zingiberis Rhizoma per capsule, qid), while the placebo group received the same number of identical looking capsules per day. The crossover occurred after 3 months of therapy. Results were evaluated by a 100mm visual analog scale (VAS) of pain on movement and of handicap. RESULTS: Eight patients dropped out because of inefficacy, three from group 1 (ginger extract first) and five from group 2 (placebo first). One patient from group 1 and one from group 2 dropped out because of heartburn (while they were on ginger extract). Twenty patients completed the study period of 24 weeks and 19 that of 48 weeks follow-up. By the end of 24 weeks there was a highly statistically significant difference between the VAS of pain and handicap of the two groups (P<0.001). However, at crossover both groups showed a statistically significant decrease in VAS of pain on movement and of handicap, but the differences between the groups did not reach statistical significance. CONCLUSIONS: Zintona EC was as effective as placebo during the first 3 months of the study, but at the end of 6 months, 3 months after crossover, the ginger extract group showed a significant superiority over the placebo group.
机译：目的：评估姜提取物（Zintona EC）对淋病患者的疗效。材料与方法：随机分为双盲，安慰剂对照，6个月交叉研究，对年龄为42-85岁的29例有症状性角膜炎（ACR标准）的患者（6例男性和23例女性）进行了研究。持续时间。给治疗组服用姜提取物（每粒250毫克黄姜生姜），而安慰剂组每天接受相同数量的相同外观的胶囊。治疗3个月后发生交叉。通过100毫米视觉模拟量表（VAS）对运动和残障疼痛进行评估。结果：八名患者因无效而退学，第一组三名（姜提取物第一），第二组五名（安慰剂第一）。第一组的一名患者和第二组的一名患者因胃灼热（正在服用姜汁）而退学。 20名患者完成了24周的研究期，其中19个完成了48周的随访。到24周结束时，两组的疼痛和残障的VAS差异具有统计学意义（P <0.001）。但是，在交叉时，两组的运动疼痛和残障疼痛的VAS均显示出统计学上的显着降低，但是两组之间的差异并未达到统计学意义。结论：Zintona EC在研究的前3个月中与安慰剂一样有效，但是在6个月后，即分频后3个月，生姜提取物组显示出明显优于安慰剂组的优势。

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