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首页> 外文期刊>Osteoarthritis and cartilage >Early osteoarthritic changes of human femoral head cartilage subsequent to femoro-acetabular impingement.
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Early osteoarthritic changes of human femoral head cartilage subsequent to femoro-acetabular impingement.

机译：股骨-髋臼撞击后，人股骨头软骨的早期骨关节炎改变。

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OBJECTIVE: To use the surgical samples of patients with femoro-acetabular impingement due to a nonspherical head to analyze tissue morphology and early cartilage changes in a mechanical model of hip osteoarthritis (OA). DESIGN: An aberrant nonspherical shape of the femoral head has been assumed to cause an abutment conflict (impingement mechanism) of the hip with subsequent cartilage lesions of the acetabular rim and surface alterations of the nonspherical portion of the head. In this study, 22 samples of the nonspherical portions of the head have been obtained during hip surgery from young adults (mean 30.4 years, range 19-45 years) with an impingement conflict. The samples were first compared with tissue from the same area obtained from six age-matched deceased persons (control group) with normal hip morphology and second with cartilage from 14 older patients with advanced OA. All samples were characterized histologically and hyaline cartilage was graded according to the Mankin criteria. They were further subjected to examination on a molecular basis by immunohistology for cartilage oligomeric matrix protein (COMP), tenascin-C and a collagenase cleavage product (COL2-3/4C(long)) and by in situ hybridization for collagen type I and collagen type II. RESULTS: All samples from the patient group revealed hyaline cartilage with degenerative signs. According to the Mankin criteria, the cartilage alterations were significantly different when compared with the control group (p=0.007) but were less distinct when compared with cartilage from patients with advanced OA (p=0.014). Positive staining and distribution pattern for COMP, tenascin-C and COL2-3/4C(long) showed similarities between the samples from the impingement group and osteoarthritic cartilage but they were distinctly different when compared with healthy cartilage. Levels of collagen I and II transcripts were upregulated in 6 and 10, respectively, of the 14 samples with OA and in 9 and 12, respectively, of the 22 samples from the impingement group. None of the samples from the control group showed upregulation of Collagen I and II mRNA. CONCLUSIONS: The aberrant nonspherical portion of the femoral head in young patients with an impingement conflict consists of hyaline cartilage which shows clear degenerative signs similar to the findings in osteoarthritic cartilage. The tissue alterations are distinctly different when compared with a control group, which substantiates an impingement conflict as an early mechanism for degeneration at the hip joint periphery.
机译：目的：使用非球形头部导致股骨-髋臼撞击的患者的手术样本分析髋骨关节炎（OA）力学模型的组织形态和早期软骨变化。设计：假设股骨头的非球形异常会导致髋部的抵接冲突（撞击机制），继而引起髋臼缘软骨损伤和头部非球形部分的表面改变。在这项研究中，在髋关节手术期间从发生碰撞冲突的年轻人（平均30.4岁，范围19-45岁）中获得了22个头部非球形部分的样本。首先将样本与来自六个年龄相匹配的髋关节形态正常的死者（对照组）的相同区域的组织进行比较，其次与来自14例晚期OA的老年患者的软骨进行比较。对所有样品进行组织学鉴定，并根据Mankin标准对透明软骨进行分级。通过免疫组织学对他们的软骨低聚基质蛋白（COMP），肌腱蛋白C和胶原酶裂解产物（COL2-3 / 4C（long））进行分子检查，并通过原位杂交检查I型胶原和胶原蛋白类型II。结果：患者组的所有样本均显示出具有退化迹象的透明软骨。根据Mankin标准，与对照组相比，软骨改变显着不同（p = 0.007），而与晚期OA患者的软骨相比则差异不大（p = 0.014）。 COMP，肌腱蛋白-C和COL2-3 / 4C（长）的阳性染色和分布图显示，冲击组的样品与骨关节炎软骨之间具有相似性，但与健康软骨相比却有明显差异。冲击组的14个OA样品中，分别有6个和10个胶原蛋白I和II转录本水平上调，22个样品中有9个和9个胶原蛋白分别有12个上调。对照组的样品均未显示I型和II型胶原蛋白的上调。结论：患有撞击冲突的年轻患者的股骨头异常非球形部分由透明软骨组成，透明软骨具有明显的退化迹象，与骨关节炎软骨相似。与对照组相比，组织改变明显不同，后者证实了撞击冲突是髋关节周围变性的早期机制。

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