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首页> 外文期刊>Osteoarthritis and cartilage >Intra-articular hyaluronate in experimental rabbit osteoarthritis can prevent changes in cartilage proteoglycan content.
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Intra-articular hyaluronate in experimental rabbit osteoarthritis can prevent changes in cartilage proteoglycan content.

机译：实验兔骨关节炎的关节内透明质酸可预防软骨蛋白聚糖含量的变化。

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OBJECTIVE: The purpose of this study was to determine the effects of intra-articular injections of high molecular weight (2000 kDa) sodium hyaluronate (HA) on the progression of articular cartilage degeneration in a rabbit partial medial meniscectomy model of osteoarthritis. DESIGN: Six experimental groups included normal, sham operated, and operated and injected animals, the latter injected once-weekly (for two weeks or twelve weeks, beginning four weeks after surgery) with either 1% (w/v) HA or phosphate buffered saline (PBS). Following assessment of gross morphology, serial adjacent blocks of full-depth articular cartilage were prepared from the tibial condyle for analysis of total water, hydroxyproline, DNA and proteoglycan (uronic acid) content, as well as the ratio of galactosamine to glucosamine. Samples were sub-divided into inner (medial) and outer (lateral) regions. RESULTS: No morphological differences were recognized between joints injected with PBS and those receiving HA. When analysed biochemically, there were no significant differences in hydration, hydroxyproline or DNA content between the experimental groups. In contrast, HA injection did affect changes in proteoglycan content. Expressed per tissue dry weight, uronic acid content in the operated group injected with PBS for two weeks was lower than normal (P<0.02), a result not seen in the corresponding HA injected group. After 12 weeks of PBS injections, uronic acid content (per dry weight) was higher than normal (P<0.01), an effect again not observed in the corresponding HA injected group. Results for the galactosamine: glucosamine ratio showed a reduction after 12 weeks of injections, but no differences between PBS and HA injected groups. CONCLUSIONS: Once-weekly, intra-articular injection of high molecular weight HA can prevent changes in proteoglycan content in tibial condylar articular cartilage, compared to PBS injected controls, in the rabbit partial meniscectomy model of osteoarthritis.
机译：目的：本研究旨在确定高分子量（2000 kDa）透明质酸钠（HA）的关节腔内注射对兔骨关节炎的半月板内侧半月板切除模型中关节软骨退变的影响。设计：六个实验组包括正常，假手术，手术和注射的动物，后者每周注射一次（术后两周或十二周，从术后四周开始），注射1％（w / v）HA或磷酸盐缓冲液盐水（PBS）。在评估总体形态后，从胫骨dy制备一系列相邻的全深度关节软骨块，以分析​​总水，羟脯氨酸，DNA和蛋白聚糖（糖醛酸）的含量，以及半乳糖胺与葡萄糖胺的比率。将样品细分为内部（内侧）和外部（外侧）区域。结果：注射PBS的关节与接受HA的关节之间没有发现形态学差异。生化分析时，实验组之间的水合作用，羟脯氨酸或DNA含量没有显着差异。相反，HA注射确实会影响蛋白聚糖含量的变化。以每组织干重表示，注射PBS 2周的手术组中的尿酸含量低于正常水平（P <0.02），在相应的HA注射组中未见结果。 PBS注射12周后，尿酸含量（每干重）高于正常水平（P <0.01），在相应的HA注射组中也未观察到这种作用。半乳糖胺：氨基葡萄糖比率的结果显示，注射12周后降低，但PBS和HA注射组之间无差异。结论：与PBS注射的对照组相比，在骨关节炎的兔子半月板切除模型中，每周一次高分子量HA的关节内注射可以防止胫骨con突软骨中蛋白聚糖含量的变化。

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