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首页> 外文期刊>Osteoarthritis and cartilage >In vivo comparison of delayed gadolinium-enhanced MRI of cartilage and delayed quantitative CT arthrography in imaging of articular cartilage
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In vivo comparison of delayed gadolinium-enhanced MRI of cartilage and delayed quantitative CT arthrography in imaging of articular cartilage

机译：延迟delayed增强MRI和延迟定量CT关节造影在关节软骨成像中的体内比较

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Objective: To compare delayed gadolinium-enhanced magnetic resonance imaging (MRI) of cartilage (dGEMRIC) and delayed quantitative computed tomography (CT) arthrography (dQCTA) to each other, and their association to arthroscopy. Additionally, the relationship between dGEMRIC with intravenous (dGEMRICIV) and intra-articular contrast agent administration (dGEMRICIA) was determined. Design: Eleven patients with knee pain were scanned at 3 T MRI and 64-slice CT before arthroscopy. dQCTA was performed at 5 and 45 min after intra-articular injection of ioxaglate. Both dGEMRICIV and dGEMRICIA were performed at 90 min after gadopentetate injection. dGEMRIC indices and change in relaxation rates (??R1) were separately calculated for dGEMRICIV and dGEMRICIA. dGEMRIC and dQCTA parameters were calculated for predetermined sites at the knee joint that were International Cartilage Repair Society (ICRS) graded in arthroscopy. Results: dQCTA normalized with the contrast agent concentration in synovial fluid (SF) and dGEMRICIV correlated significantly, whereas dGEMRICIA correlated with the normalized dQCTA only when dGEMRICIA was also normalized with the contrast agent concentration in SF. Correlation was strongest between normalized dQCTA at 45 min and ??R1,IV (rs = 0.72 [95% CI 0.56-0.83], n = 49, P 0.01) and ??R1,IA normalized with ??R1 in SF (rs = 0.70 [0.53-0.82], n = 52, P 0.01). Neither dGEMRIC nor dQCTA correlated with arthroscopic grading. dGEMRICIV and non-normalized dGEMRICIA were not related while ??R1,IV correlated with normalized ??R1,IA (rs = 0.52 [0.28-0.70], n = 50, P 0.01). Conclusions: This study suggests that dQCTA is in best agreement with dGEMRICIV at 45 min after CT contrast agent injection. dQCTA and dGEMRIC were not related to arthroscopy, probably because the remaining cartilage is analysed in dGEMRIC and dQCTA, whereas in arthroscopy the absence of cartilage defines the grading. The findings indicate the importance to take into account the contrast agent concentration in SF in dQCTA and dGEMRICIA. ? 2012 Osteoarthritis Research Society International.
机译：目的：比较延迟delayed增强磁共振成像（MRI）和延迟定量计算机体层摄影（CT）关节造影（dQCTA）的关系，以及它们与关节镜的关系。另外，确定了静脉内dGEMRIC（dGEMRICIV）与关节内造影剂给药（dGEMRICIA）之间的关系。设计：在进行关节镜检查之前，对11例膝关节疼痛患者进行了3 T MRI和64层CT扫描。关节内注射ioxaglate后5和45分钟进行dQCTA。注射戊ado戊酸酯后90分钟进行dGEMRICIV和dGEMRICIA。分别计算dGEMRICIV和dGEMRICIA的dGEMRIC指数和松弛率变化（ΔR1）。对于关节镜检查中国际软骨修复协会（ICRS）分级的膝关节预定部位，计算dGEMRIC和dQCTA参数。结果：用滑液（SF）中的造影剂浓度标准化的dQCTA与dGEMRICIV显着相关，而仅当dGEMRICIA也用SF中的造影剂浓度标准化时，dGEMRICIA与标准化的dQCTA相关。在45分钟时标准化的dQCTA与ΔR1，IV（rs = 0.72 [95％CI 0.56-0.83]，n = 49，P <0.01）和ΔR1，IA之间的相关性最强，并用ΔRR1标准化rs = 0.70 [0.53-0.82]，n = 52，P <0.01）。 dGEMRIC和dQCTA均与关节镜分级无关。 dGEMRICIV和未归一化的dGEMRICIA不相关，而ΔR1，IV与归一化ΔR1，IA相关（rs = 0.52 [0.28-0.70]，n = 50，P <0.01）。结论：这项研究表明，在注射CT造影剂后45分钟，dQCTA与dGEMRICIV最佳吻合。 dQCTA和dGEMRIC与关节镜检查无关，可能是因为在dGEMRIC和dQCTA中分析了剩余的软骨，而在关节镜检查中，没有软骨定义了分级。这些发现表明了在dQCTA和dGEMRICIA中考虑到SF中造影剂浓度的重要性。 ？ 2012年国际骨关节炎研究学会。

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