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首页> 外文期刊>Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA >Short-term prophylaxis against estrogen depletion-induced bone loss with calcitriol does not provide long-term beneficial effects on cancellous bone mass or structure in ovariectomized rats.
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Short-term prophylaxis against estrogen depletion-induced bone loss with calcitriol does not provide long-term beneficial effects on cancellous bone mass or structure in ovariectomized rats.

机译：用骨化三醇短期预防雌激素耗竭引起的骨质流失不能对卵巢切除大鼠的松质骨质量或结构产生长期的有益影响。

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摘要

It was the aim of the present study to investigate whether a 2-month prophylaxis of postovariectomy bone loss with low-dose calcitriol would have long-lasting beneficial effects on cancellous bone mass or structure after its withdrawal in rats. Six-month-old female Fischer 344 rats were either ovariectomized (OVX) or sham-operated (SHAM). Groups of SHAM and OVX rats were orally treated with either 0.05 microgram calcitriol/kg per day or vehicle for 2 months postovariectomy, starting immediately after ovariectomy. Thereafter, the rats were maintained without treatment for another 4 months. Half the animals in each group were killed 2 months postovariectomy; the rest of the rats were killed 6 months postovariectomy. Cancellous bone histomorphometry was performed on the first lumbar vertebral body and on the proximal tibial metaphysis. Administration of low-dose calcitriol to SHAM and OVX rats resulted in hypercalciuria, but not hypercalcemia. By 2 months postovariectomy, calcitriol treatment of OVX rats had completely prevented tibial trabecular bone loss, and had increased vertebral cancellous bone mass in SHAM and OVX rats by about 30% over the level observed in SHAM vehicle controls. However, at the end of the experiment, i.e. 4 months after withdrawal of calcitriol, cancellous bone mass and structure in both the vertebrae and the tibiae of calcitriol-treated OVX rats were almost identical to those of vehicle-treated OVX rats. We conclude that prevention of bone loss with low-dose calcitriol during the phase of acute estrogen deficiency, when bone turnover is maximally increased, does not provide long-term beneficial effects on cancellous bone mass or structure in OVX rats. If extrapolated to postmenopausal women, this study would suggest that prophylaxis against postmenopausal bone loss with short-acting antiresorptive substances during only the first few years after menopause will probably not reduce the risk of postmenopausal osteoporosis later in life.
机译：本研究的目的是研究用低剂量骨化三醇预防2个月的卵巢切除术后骨丢失是否会对大鼠松质骨质量或结构产生持久的有益影响。六个月大的雌性Fischer 344大鼠经卵巢切除（OVX）或假手术（SHAM）。 SHAM和OVX组大鼠在卵巢切除术后立即开始口服或每天用0.05微克骨化三醇/ kg或口服赋形剂治疗2个月。此后，将大鼠保持未经治疗的另外4个月。卵巢切除术后2个月，每组一半的动物被杀死;其余大鼠在卵巢切除术后6个月被杀死。在第一个腰椎椎体和胫骨近端干physi端进行松质骨组织形态测定。向SHAM和OVX大鼠施用小剂量骨化三醇可导致高钙尿症，但不会导致高钙血症。卵巢切除术后2个月，骨化三醇治疗OVX大鼠已完全预防了胫骨小梁骨丢失，并且使SHAM和OVX大鼠的椎骨松质骨量增加了约30％，超过了SHAM载体对照中观察到的水平。然而，在实验结束时，即在撤消骨化三醇后4个月，骨化三醇治疗的OVX大鼠的椎骨和胫骨中的松质骨质量和结构与溶媒治疗的OVX大鼠几乎相同。我们得出的结论是，当雌激素缺乏症急性期骨量最大增加时，小剂量骨化三醇预防骨质流失不会对OVX大鼠的松质骨量或结构产生长期的有益影响。如果将其推广至绝经后妇女，则该研究表明，在绝经后的最初几年中，使用短效抗再吸收物质预防绝经后骨质流失可能不会降低绝经后骨质疏松症的发病风险。

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