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首页> 外文期刊>Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA >Fracture risk in children with a forearm injury is associated with volumetric bone density and cortical area (by peripheral QCT) and areal bone density (by DXA).
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Fracture risk in children with a forearm injury is associated with volumetric bone density and cortical area (by peripheral QCT) and areal bone density (by DXA).

机译：前臂损伤患儿的骨折风险与骨密度和皮质面积（通过外周QCT）和面骨密度（通过DXA）有关。

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Children who sustain a forearm fracture when injured have lower bone density throughout their skeleton, and have a smaller cortical area and a lower strength index in their radius. Odds ratios per SD decrease in bone characteristics measured by peripheral quantitative computed tomography (pQCT) and dual-energy X-ray absorptiometry (DXA) were similar (1.28 to 1.41). INTRODUCTION: Forearm fractures are common in children. Bone strength is affected by bone mineral density (BMD) and bone geometry, including cross-sectional dimensions and distribution of mineral. Our objective was to identify bone characteristics that differed between children who sustained a forearm fracture compared to those who did not fracture when injured. METHODS: Children (5-16 years) with a forearm fracture (cases, n = 224) and injured controls without fracture (n = 200) were enrolled 28 +/- 8 days following injury. Peripheral QCT scans of the radius (4% and 20% sites) were obtained to measure volumetric BMD (vBMD) of total, trabecular and cortical bone compartments, and bone geometry (area, cortical thickness, and strength strain index [SSI]). DXA scans (forearm, spine, and hip) were obtained to measure areal BMD (aBMD) and bone area. Receiver operating characteristic (ROC) analyses were used to assess screening performance of bone measurements. RESULTS: At the 4% pQCT site, total vBMD, but not trabecular vBMD or bone area, was lower (-3.4%; p = 0.02) in cases than controls. At the 20% site, cases had lower cortical vBMD (-0.9%), cortical area (-2.8%), and SSI (-4.6%) (p < 0.05). aBMD, but not bone area, at the 1/3 radius, spine, and hip were 2.7-3.3% lower for cases (p < 0.01). Odds ratios per 1 SD decrease in bone measures (1.28-1.41) and areas under the ROC curves (0.56-0.59) were similar for all bone measures. CONCLUSIONS: Low vBMD, aBMD, cortical area, and SSI of the distal radius were associated with an increased fracture risk. Interventions to increase these characteristics are needed to help reduce forearm fracture occurrence.
机译：受伤时遭受前臂骨折的儿童的整个骨骼骨密度较低，皮质面积较小，半径强度指数较低。通过外周定量计算机断层扫描（pQCT）和双能X线骨密度仪（DXA）测得的每位SD骨质下降的赔率相似（1.28至1.41）。简介：前臂骨折常见于儿童。骨强度受骨矿物质密度（BMD）和骨骼几何形状（包括横截面尺寸和矿物质分布）的影响。我们的目标是确定在遭受前臂骨折的儿童与受伤时未骨折的儿童之间不同的骨骼特征。方法：受伤后28 +/- 8天入选了前臂骨折的儿童（5-16岁）（病例，n = 224）和无骨折的受伤对照组（n = 200）。获得了半径（4％和20％部位）的周边QCT扫描，以测量全部，小梁和皮质骨腔室的体积BMD（vBMD），以及骨骼的几何形状（面积，皮质厚度和强度应变指数[SSI]）。进行了DXA扫描（前臂，脊椎和髋部）以测量区域BMD（aBMD）和骨骼面积。接收器工作特征（ROC）分析用于评估骨测量的筛查性能。结果：在4％的pQCT部位，患者的总vBMD（而非小梁vBMD或骨面积）低于对照组（-3.4％; p = 0.02）。在20％的部位，病例的皮质vBMD（-0.9％），皮质面积（-2.8％）和SSI（-4.6％）较低（p <0.05）。在1/3半径处，脊柱和髋部的aBMD（而非骨骼区域）降低了2.7-3.3％（p <0.01）。对于所有骨量度，骨量度（1.28-1.41）和ROC曲线下面积（0.56-0.59）的每1 SD降低几率均相似。结论：低vBMD，aBMD，皮质区域和远端radius骨SSI与骨折风险增加相关。需要采取干预措施来增加这些特征，以帮助减少前臂骨折的发生。

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