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Yeast prions and human prion?like proteins: sequence features and prediction methods

机译：酵母病毒和人类病毒样蛋白：序列特征和预测方法

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摘要

Prions are self-propagating infectious protein isoforms. A growing number of prions have been identified in yeast, each resulting from the conversion of soluble proteins into an insoluble amyloid form. These yeast prions have served as a powerful model system for studying the causes and consequences of prion aggregation. Remarkably, a number of human proteins containing prion-like domains, defined as domains with compositional similarity to yeast prion domains, have recently been linked to various human degenerative diseases, including amyotrophic lateral sclerosis. This suggests that the lessons learned from yeast prions may help in understanding these human diseases. In this review, we examine what has been learned about the amino acid sequence basis for prion aggregation in yeast, and how this information has been used to develop methods to predict aggregation propensity. We then discuss how this information is being applied to understand human disease, and the challenges involved in applying yeast prediction methods to higher organisms.
机译：ions病毒是自繁殖的感染性蛋白亚型。在酵母中已鉴定出越来越多的病毒，每种都源于可溶性蛋白质转化为不溶性淀粉样蛋白形式。这些酵母病毒已成为研究studying病毒聚集的原因和后果的强大模型系统。引人注目的是，许多含有proteins病毒样结构域的人类蛋白质被定义为与酵母病毒蛋白结构域组成相似的结构域，最近已与各种人类变性疾病（包括肌萎缩性侧索硬化）联系在一起。这表明从酵母病毒学到的教训可能有助于理解这些人类疾病。在这篇综述中，我们检查了关于酵母中pr病毒聚集的氨基酸序列基础的知识，以及如何将这些信息用于开发预测聚集倾向的方法。然后，我们讨论如何将此信息用于理解人类疾病，以及将酵母预测方法应用于高等生物的挑战。

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