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首页> 外文期刊>Scandinavian journal of urology >Tumor necrosis factor-alpha expression in patients with obstructive benign prostatic hyperplasia is associated with a higher incidence of asymptomatic inflammatory prostatitis NIH category IV and prostatic calcification
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Tumor necrosis factor-alpha expression in patients with obstructive benign prostatic hyperplasia is associated with a higher incidence of asymptomatic inflammatory prostatitis NIH category IV and prostatic calcification

机译：梗阻性前列腺增生患者的肿瘤坏死因子-α表达与无症状性炎性前列腺炎NIH IV级和前列腺钙化的发生率更高相关

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Objective. The aim of this study was to investigate the association of the expression of tumor necrosis factor- (TNF-) with asymptomatic inflammatory prostatitis National Institutes of Health (NIH) category IV and prostatic calculi, in patients with obstructive benign prostatic hyperplasia (BPH) treated by transurethral electroresection of the prostate (TURP). Materials and methods. Ninety-six patients with obstructive BPH and TURP were evaluated in a prospective study. Based on a preoperative transrectal ultrasound examination of the prostate gland, patients were divided into two groups, one with prostatic calculi (n = 31) and one without (n = 65). Prostatitis NIH category IV was classified according to Irani's histological grading system (Irani et al. J Urol 1997;157:1301-3). Associations between the incidence of prostatic calculi, histological prostatitis, TNF- expression, prostate-specific antigen, uric acid, cholesterol, triglycerides, C-reactive protein, International Prostate Symptom Score (IPSS), the International Index for Erectile Function (IIEF-5) and the NIH-Chronic Prostatitis Symptom Index Score (NIH-CPSI) were analyzed. Results. Prostatitis was confirmed by histological investigation in 71.9% of patients: 83.9% of those with prostatic calculi versus 66.1% of those without (p < 0.04). TNF- expression was significantly higher in patients with prostatic calculi. Association calculations yielded significant values for the severity (histological grading) of inflammation (p < 0.029), TNF- expression (p < 0.007), uric acid (p < 0.005), cholesterol (p < 0.028) and the NIH-CPS subdomain of urinary symptoms (p < 0.044) in patients with prostatic calculi. Conclusions. In patients with obstructive BPH, prostatic calculi were found on ultrasound in one-third of the cases, and histological NIH category IV prostatitis in two-thirds of cases. The incidence of both prostatitis NIH category IV and TNF- expression was significantly higher in patients with prostatic calculi than in those without.
机译：目的。这项研究的目的是调查在患有阻塞性良性前列腺增生（BPH）的患者中，肿瘤坏死因子-（TNF-）的表达与无症状炎性前列腺炎（NIH）IV类和前列腺结石的关系经尿道前列腺电切术（TURP）。材料和方法。在一项前瞻性研究中评估了96例阻塞性BPH和TURP的患者。根据术前对前列腺进行的直肠超声检查，将患者分为两组，一组患有前列腺结石（n = 31），另一组没有前列腺结石（n = 65）。根据伊朗的组织学分级系统将IV类前列腺炎分类为NIH（Irani等，J Urol 1997; 157：1301-3）。前列腺结石的发生率，组织学前列腺炎，TNF表达，前列腺特异性抗原，尿酸，胆固醇，甘油三酸酯，C反应蛋白，国际前列腺症状评分（IPSS），国际勃起功能指数（IIEF-5）之间的关联）和NIH-慢性前列腺炎症状指数评分（NIH-CPSI）。结果。经组织学检查证实有71.9％的患者患有前列腺炎：患有前列腺结石的患者为83.9％，而没有前列腺结石的患者为66.1％（p <0.04）。前列腺结石患者的TNF-表达明显更高。关联计算得出炎症的严重程度（组织学分级）（p <0.029），TNF-表达（p <0.007），尿酸（p <0.005），胆固醇（p <0.028）和NIH-CPS子域的重要值前列腺结石患者的泌尿系统症状（p <0.044）。结论。在阻塞性BPH患者中，超声检查发现前列腺结石占三分之一，三分之二是组织学NIH IV类前列腺炎。前列腺结石患者的IV型前列腺炎NIH和TNF-表达的发生率均显着高于无前列腺结石的患者。

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