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首页> 外文期刊>Schizophrenia research >Diagnostic specificity of poor premorbid adjustment: Comparison of schizophrenia, schizoaffective disorder, and mood disorder with psychotic features
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Diagnostic specificity of poor premorbid adjustment: Comparison of schizophrenia, schizoaffective disorder, and mood disorder with psychotic features

机译：病前适应性差的诊断特异性：精神分裂症，精神分裂症和精神病性精神障碍的比较

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Individuals with schizophrenia have significant deficits in premorbid social and academic adjustment compared to individuals with non-psychotic diagnoses. However, it is unclear how severity and developmental trajectory of premorbid maladjustment compare across psychotic disorders. This study examined the association between premorbid functioning (in childhood, early adolescence, and late adolescence) and psychotic disorder diagnosis in a first-episode sample of 105 individuals: schizophrenia (n = 68), schizoaffective disorder (n = 22), and mood disorder with psychotic features (n = 15). Social and academic maladjustment was assessed using the Cannon-Spoor Premorbid Adjustment Scale. Worse social functioning in late adolescence was associated with higher odds of schizophrenia compared to odds of either schizoaffective disorder or mood disorder with psychotic features, independently of child and early adolescent maladjustment. Greater social dysfunction in childhood was associated with higher odds of schizoaffective disorder compared to odds of schizophrenia. Premorbid decline in academic adjustment was observed for all groups, but did not predict diagnosis at any stage of development. Results suggest that social functioning is disrupted in the premorbid phase of both schizophrenia and schizoaffective disorder, but remains fairly stable in mood disorders with psychotic features. Disparities in the onset and time course of social dysfunction suggest important developmental differences between schizophrenia and schizoaffective disorder.
机译：与非精神病诊断者相比，精神分裂症患者的病前社会和学术适应能力明显不足。然而，目前尚不清楚病态前适应不良的严重程度和发展轨迹在精神病性疾病之间的比较。这项研究在105名患者的第一集样本中检查了病前功能（儿童时期，青春期早期和青春期晚期）与精神病性障碍诊断之间的关联：精神分裂症（n = 68），精神分裂性障碍（n = 22）和情绪具有精神病特征的疾病（n = 15）。社会和学术上的适应不良是使用Cannon-Spoor病前调整量表进行评估的。与儿童和青少年期早期适应不良无关的精神分裂症特征的情感分裂性障碍或情绪障碍的可能性相比，青春期晚期较差的社交功能与精神分裂症的可能性更高。与精神分裂症的几率相比，儿童时期更大的社会功能障碍与精神分裂症患病几率更高。观察到所有组的学业调整均出现病前下降，但并未预测任何发展阶段的诊断。结果表明，在精神分裂症和精神分裂症的发病前阶段，社会功能都会受到干扰，但是在具有精神病特征的情绪障碍中，社交功能仍然保持稳定。社会功能障碍的发作和时间过程的差异表明，精神分裂症和情感分裂性障碍之间存在重要的发育差异。

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