...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Sarcoidosis, vasculitis, and diffuse lung diseases: official journal of WASOG >Cytokine profile of broncho-alveolar lavage in BOOP and UIP.
【24h】

Cytokine profile of broncho-alveolar lavage in BOOP and UIP.

机译：BOOP和UIP中支气管肺泡灌洗液的细胞因子谱。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: The aim of our study was to compare clinical and BAL features of patients with bronchiolitis obliterans organizing pneumonia (BOOP) with those of patients with usual interstitial pneumonia (UIP) and control subjects. PATIENTS AND METHODS: This study reports on 14 patients with idiopathic BOOP. Diagnosis was made upon histology. Lung function tests were mostly normal. Chest X-ray and CT showed always a patchy consolidation, often associated with ground glass pattern. BAL was performed for cytology and for ELISA assessment of several cytokines (IL8, ILI0, IL12, gamma-interferon, IL 18, monocyte chemoattractant protein- 1). RESULTS: Cytology of BAL in BOOP showed a pattern of lymphocytic alveolitis (Lymphocytes: 0.36 x 10(6)/ml) associated with an increase in neutrophil and eosinophil counts (0.13 and 0.04 x 10(6)/ml respectively). Mean BALf levels in pg/ml of MCP-1, IL12 and IL18 were significantly increased in BOOP with respect to controls and UIP patients, while in UIP patients only a significant increase of IL8, MCP-1 and IL18 with respect to controls was detected. In addition, BALf levels of IL10, an anti-inflammatory cytokine, were significantly higher in BOOP patients with respect to controls and UIP patients. CONCLUSION: These findings are consistent with a marked degree of macrophage and lymphocyte activation in BOOP with an expansion of T helper-1 response. The concomitant increase of IL10 could be related to a limitation of the inflammatory process and the fibrotic evolution typical of this clinical picture.
机译：背景：我们的研究目的是比较闭塞性细支气管炎组织性肺炎（BOOP）患者与普通间质性肺炎（UIP）患者和对照对象的临床和BAL特征。患者与方法：本研究报道了14例特发性BOOP患者。根据组织学进行诊断。肺功能检查大多正常。胸部X线和CT扫描显示总是有片状巩固，通常与毛玻璃样有关。 BAL用于细胞学检查和ELISA评估几种细胞因子（IL8，ILI0，IL12，γ-干扰素，IL 18，单核细胞趋化蛋白-1）。结果：BOOP中BAL的细胞学检查显示淋巴细胞性肺泡炎（淋巴细胞：0.36 x 10（6）/ ml）与中性粒细胞和嗜酸性粒细胞计数增加（分别为0.13和0.04 x 10（6）/ ml）相关。与对照组和UIP患者相比，BOOP的平均BALf水平以pg / ml的MCP-1，IL12和IL18显着增加，而在UIP患者中，仅检测到IL8，MCP-1和IL18相对于对照组的显着增加。另外，相对于对照组和UIP患者，BOOP患者中IL10（一种抗炎细胞因子）的BALf水平显着更高。结论：这些发现与BOOP中巨噬细胞和淋巴细胞活化程度的增加以及T helper-1应答的增加是一致的。 IL10的同时升高可能与该临床表现中典型的炎症过程和纤维化演变的局限性有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号