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首页> 外文期刊>Sarcoidosis, vasculitis, and diffuse lung diseases: official journal of WASOG >Exaggerated TNFalpha release of alveolar macrophages in corticosteroid resistant sarcoidosis.
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Exaggerated TNFalpha release of alveolar macrophages in corticosteroid resistant sarcoidosis.

机译：糖皮质激素抵抗结节病中肺泡巨噬细胞的TNFalpha释放过大。

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BACKGROUND AND AIM OF WORK: The aim of the present study was to determine the TNFalpha release of cultured alveolar macrophages (AM) and the bronchoalveolar lavage (BAL) cellular profile in 35 patients suffering from long lasting sarcoidosis. METHODS: The AM TNFalpha release and the BAL cellular profile of 35 patients with a mean duration of sarcoidosis of 10.4 +/- 1.3 years at the time of BAL was compared to 35 healthy controls. RESULTS: The BAL profile of 12 sarcoid patients with a stable disease was similar to that known from acute sarcoidosis. Sarcoid patients with progressive disease (n = 12) and sarcoid patients with corticosteroid resistant disease (n = 11) were characterised by a normal CD4/CD8 ratio and a significant increase of BAL neutrophils (2.7 +/- 1.0% and 3.8 +/- 1.1%, respectively). The AM TNFalpha release of sarcoid patients with stable disease did not differ significantly from controls (523 +/- 124 pg/ml vs. 410 +/- 104 pg/ml). In contrast, we observed a significantly elevated TNFalpha release in sarcoid patients with progressive (2,124 +/- 550 pg/ml; p < 0.01) as well as in those with a corticosteroid resistant disease (1,585 +/- 520 pg/ml; p < 0.01) compared to controls. CONCLUSION: Chronic sarcoid patients in a progressive phase of the disease and those with a corticosteroid resistant disease are characterised by a significantly increased TNFalpha release of cultured AM. Our results support the usage of chimeric anti-TNFalpha antibodies as an alternative therapeutic regimen in chronic corticosteroid resistant sarcoidosis.
机译：背景和工作目的：本研究的目的是确定35例长期结节病患者的培养肺泡巨噬细胞（AM）和支气管肺泡灌洗（BAL）细胞的TNFalpha释放。方法：将35名BAL时结节病病程平均为10.4 +/- 1。3年的患者的AM TNFalpha释放和BAL细胞谱与35名健康对照者进行比较。结果：12例结节病患者的BAL谱与急性结节病相似。具有进展性疾病的结节病患者（n = 12）和具有皮质类固醇抵抗性疾病的结节病患者（n = 11）的特征是CD4 / CD8比率正常，BAL中性粒细胞显着增加（2.7 +/- 1.0％和3.8 +/-分别为1.1％）。患有稳定疾病的结节病患者的AM TNFalpha释放与对照组无显着差异（523 +/- 124 pg / ml与410 +/- 104 pg / ml）。相比之下，我们观察到进行性（2,124 +/- 550 pg / ml; p <0.01）的结节病患者以及患有糖皮质激素抵抗性疾病（1,585 +/- 520 pg / ml; p的结节病患者）TNFalpha释放明显升高。 <0.01）。结论：处于疾病进展阶段的慢性结节病患者和患有皮质类固醇抗性疾病的患者的特征在于培养的AM的TNFα释放显着增加。我们的结果支持在慢性皮质类固醇耐药结节病中使用嵌合抗TNFα抗体作为替代治疗方案。

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