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首页> 外文期刊>Sarcoidosis, vasculitis, and diffuse lung diseases: official journal of WASOG >Sarcoid arthritis: a review of clinical features, pathology and therapy.
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Sarcoid arthritis: a review of clinical features, pathology and therapy.

机译：结节性关节炎：临床特征，病理学和治疗方法的综述。

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摘要

The rheumatic manifestations of sarcoidosis include inflammatory arthritis, periarticular soft tissue swelling, tenosynovitis, dactylitis, bone involvement and myopathy. Two types of arthritis that differ in clinical course and prognosis are recognized. Acute sarcoid arthritis is self-limiting and resolves without permanent sequelae. Chronic sarcoid arthritis although less common can progress to cause joint deformities. There are proliferative and inflammatory changes in the synovium and non-caseating granulomas are seen in half of patients. The pathogenesis of sarcoid arthritis is not well understood, however genetic and environmental factors are important. Drug therapy of sarcoid arthritis with nonsteroidal anti-inflammatory agents, corticosteroids, colchicine, antimalarials and/or immunosuppressive medications is based mainly on open label uncontrolled studies. This review focuses on the current knowledge on the various features of sarcoid arthritis including clinical presentation, course, imaging, and pathology. Recent developments in the usage of anti-tumor necrosis factor therapy for sarcoidosis will be reviewed.
机译：结节病的风湿表现包括炎性关节炎，关节周围软组织肿胀，腱鞘炎，齿根炎，骨受累和肌病。人们认识到两种在临床过程和预后方面不同的关节炎。急性结节状关节炎是自限性的，可以永久消除后遗症。慢性结节状关节炎虽然不常见，但会发展成导致关节畸形。滑膜中有增生和炎症变化，一半患者可见非干酪性肉芽肿。结节性关节炎的发病机理尚不清楚，但是遗传和环境因素很重要。使用非甾体类抗炎药，皮质类固醇，秋水仙碱，抗疟疾药和/或免疫抑制药对类结节性关节炎的药物治疗主要基于开放标签的非对照研究。这篇综述重点关注结节性关节炎的各种特征的当前知识，包括临床表现，病程，影像学和病理学。结节病的抗肿瘤坏死因子疗法的使用的最新进展将进行审查。

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