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首页> 外文期刊>Scandinavian journal of urology >Combination of real-time elastography and urine prostate cancer gene 3 (PCA3) detects more than 97% of significant prostate cancers
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Combination of real-time elastography and urine prostate cancer gene 3 (PCA3) detects more than 97% of significant prostate cancers

机译：实时弹性成像和尿液前列腺癌基因3（PCA3）的结合可检测出97％以上的重要前列腺癌

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Objective. The prostate cancer gene 3 (PCA3) score in urine is a promising biomarker for prostate cancer. Real-time elastography (RTE) is a well-documented ultrasound modality. The objective of this study was to evaluate the ability to detect significant cancer foci in the prostate with these methods alone and in combination. Material and methods. From September 2009 to September 2010, 40 patients planned for radical prostatectomy underwent a PCA3 urine test and RTE before operation. A Hitachi EUB-8500 with prostate end-fire transrectal probe was used. The PCA3 score was evaluated with a standard cut-off value of 35. RTE was evaluated in correlation with whole-mount section pathology. Three patients fulfilled the criteria for insignificant prostate cancer and were excluded from the study. Results. The PCA3 score was increased in 26 patients (70%). RTE identified at least one tumour in 33 out of 37 patients (89%). RTE detected the largest tumour in 27 out of 37 patients (73%). More than one cancer was present in 29 patients and RTE identified more than one tumour in 13 of these. The RTE was false positive in four patients. The PCA3 score was increased in three out of four false-negative RTE patients. By combining both methods, 36 out of 37 patients (97%) with significant prostate cancer were detected. Conclusions.The combination of PCA3 score and RTE detected 97% of significant prostate cancers. The combinative use of RTE and PCA3 will be further investigated in an unselected series of men with suspected prostate cancer.
机译：目的。尿液中的前列腺癌基因3（PCA3）评分是前列腺癌的有前途的生物标志物。实时弹性成像（RTE）是有据可查的超声检查方法。这项研究的目的是评估单独或组合使用这些方法检测前列腺中重要癌灶的能力。材料与方法。从2009年9月至2010年9月，计划进行前列腺癌根治术的40例患者在术前接受了PCA3尿液测试和RTE。使用具有前列腺末端发射经直肠探针的日立EUB-8500。 PCA3评分的标准截断值为35。RTE与整个切片病理的相关性进行了评估。三名患者满足了微不足道的前列腺癌标准，被排除在研究之外。结果。 26名患者（70％）的PCA3评分增加。 RTE在37位患者中的33位（89％）中至少发现了一种肿瘤。 RTE在37例患者中有27例（73％）检测到最大的肿瘤。 29例患者中存在一种以上的癌症，RTE在其中13例中识别出一种以上的肿瘤。 4例患者的RTE为假阳性。四名假阴性RTE患者中有三名PCA3评分增加。通过两种方法的组合，在37例患有严重前列腺癌的患者中，有36例被检出。结论PCA3评分和RTE的结合可检测出97％的重要前列腺癌。 RTE和PCA3的联合使用将在一系列未选择的患有前列腺癌的男性中进一步研究。

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