Constitutive p63 expression in airway basal cells. A molecular target in diffuse lung diseases.

Chilosi M; Doglioni C

首页> 外文期刊>Sarcoidosis, vasculitis, and diffuse lung diseases: official journal of WASOG >Constitutive p63 expression in airway basal cells. A molecular target in diffuse lung diseases.

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Constitutive p63 expression in airway basal cells. A molecular target in diffuse lung diseases.

机译：p63在气道基底细胞中的组成型表达。弥漫性肺疾病的分子靶标。

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The p63 gene has high homology with p53, but more complex physiologic functions, including the regulation of the maintenance of basal cells in stratified epithelia. These cells in fact express high levels of the deltaN-terminal truncated isoforms of the p63 gene that can act as dominant-negative inhibiting the activity of p53. Basal cells in human bronchi and bronchioli seem to use the same strategy, since they constitutively express high levels of p63, at variance with alveolar pneumocytes. Over-expression of these isoforms in airway basal cells can inhibit important functions of the p53-pathway, including cell cycle arrest and apoptosis. This finding underlines the key role of p63 in epithelial renewal in human lung, with important implications in the understanding of the mechanisms of tissue remodelling occurring in diffuse lung diseases.

机译：p63基因与p53具有高度同源性，但具有更复杂的生理功能，包括分层上皮中基底细胞维持的调节。实际上，这些细胞表达高水平的p63基因的δN末端截短同工型，可以作为显性负性抑制p53的活性。人支气管和支气管中的基础细胞似乎使用相同的策略，因为它们组成型表达高水平的p63，与肺泡性肺细胞不同。这些同工型在气道基底细胞中的过度表达可以抑制p53途径的重要功能，包括细胞周期停滞和凋亡。这一发现强调了p63在人肺上皮更新中的关键作用，对理解弥漫性肺部疾病中发生的组织重塑机制具有重要意义。

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《Sarcoidosis, vasculitis, and diffuse lung diseases: official journal of WASOG》 |2001年第1期|共4页
作者
Chilosi M; Doglioni C;
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正文语种 eng
中图分类肿瘤学;
关键词
Bronchi; Cell Cycle; Lung Diseases; Interstitial; Phosphoproteins; Respiratory Mucosa cytology; 支气管; 细胞周期; 肺疾病; 间质性; 磷蛋白类; 反式作用因子;

机译：Bronchi;Cell Cycle;Lung Diseases;Interstitial;Phosphoproteins;Respiratory Mucosa cytology;支气管;细胞周期;肺疾病;间质性;磷蛋白类;反式作用因子;

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1. Constitutive p63 expression in airway basal cells. A molecular target in diffuse lung diseases. [J] . Chilosi M, Doglioni C Sarcoidosis, vasculitis, and diffuse lung diseases: official journal of WASOG . 2001,第1期

机译：p63在气道基底细胞中的组成型表达。弥漫性肺疾病的分子靶标。
2. Effects of Th2 cytokines on chemokine expression in the lung: IL-13 potently induces eotaxin expression by airway epithelial cells. [J] . Li L, Xia Y, Nguyen A, The Journal of Immunology: Official Journal of the American Association of Immunologists . 1999,第5期

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4. Distinctive Signaling Pathways in the Induction of Airway MUC5B and MUC5AC Expression by PMA and Its Implication in Lung Diseases [C] . Daphne Yuan-chen Wu, Reen Wu, Sekhar P. Reddy, 第三届上海国际呼吸病研讨会暨第十四届亚太呼吸治疗学会联合会议 . 2006

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5. Trefoil factor expression profile in the airways of NIH Swiss mice and Rhesus macaques during epithelial injury and postnatal lung development. [D] . Greeley, Melanie A. 2008

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6. TP63 basal cells are indispensable during endoderm differentiation into proximal airway cells on acellular lung scaffolds [O] . Claudia Bilodeau, Sharareh Shojaie, Olivia Goltsis, 2021

机译：TP63基底细胞在细胞肺支架上的近端气道细胞中是必不可少的
7. Understanding of Molecular Aspects of Lung Carcinogenesis and New Therapeutic Target Discovery Based on Comprehensive Gene and Protein-expression Profiles [O] . Yataro Daigo, Yusuke Nakamura 2009

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8. Maximal Diffusing Capacity of the Lung in Chronic Obstructive Disease of the Airways. [R] . Shepard, R. H., Cohn, J. E., Cohen, G., 1955

机译：气道慢性阻塞性肺病患者肺内最大扩散能力。

Constitutive p63 expression in airway basal cells. A molecular target in diffuse lung diseases.

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