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首页> 外文期刊>Otolaryngology--head and neck surgery: official journal of American Academy of Otolaryngology-Head and Neck Surgery >Cellular immune defect caused by postsurgical radiation therapy in patients with head and neck cancer.
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Cellular immune defect caused by postsurgical radiation therapy in patients with head and neck cancer.

机译：头颈癌患者术后放射治疗引起的细胞免疫缺陷。

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摘要

The effects of locoregional postoperative radiation therapy (60 Gy on average) on cellular immunity were investigated in 11 patients with squamocellular carcinomas of the oral cavity, pharynx, or larynx. During radiation treatment, the total lymphocyte counts, CD8+ T-lymphocyte count, and especially CD4+ T-lymphocyte count decreased significantly. The mean CD4+ T-lymphocyte counts dropped from an average of 739/microl to 183/microl (p <0.001), and the CD4+/CD8+ quotient also decreased significantly. Not only the lymphocyte counts but also the in vitro lymphocyte stimulation responses to several mitogens decreased, with reductions averaging 10% to 50% of normal responses by the end of radiation therapy. Within 3 to 4 weeks after radiation therapy, the CD4+ T-lymphocyte counts and the in vitro lymphocyte stimulation responses showed a tendency toward normalization. This study shows that postoperative locoregional radiation therapy in patients with head and neck cancer induces a severe generalized impairment of cellular immunity.
机译：在11例口腔，咽或喉鳞状细胞癌患者中，研究了局部局部术后放射治疗（平均60 Gy）对细胞免疫的影响。在放射治疗期间，总淋巴细胞计数，CD8 + T淋巴细胞计数，尤其是CD4 + T淋巴细胞计数显着下降。平均CD4 + T淋巴细胞计数从平均值739 /微升降至183 /微升（p <0.001），CD4 + / CD8 +商也显着下降。不仅淋巴细胞计数减少，而且体外淋巴细胞对几种促分裂原的刺激反应均减少，到放射治疗结束时，平均减少了正常反应的10％至5​​0％。放射治疗后3至4周内，CD4 + T淋巴细胞计数和体外淋巴细胞刺激反应均显示趋于正常化的趋势。这项研究表明，头颈部癌患者的局部局部放射治疗会引起严重的广泛性细胞免疫损伤。

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