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首页> 外文期刊>Otolaryngology--head and neck surgery: official journal of American Academy of Otolaryngology-Head and Neck Surgery >Effects of external beam radiation on the allograft dermal implant.
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Effects of external beam radiation on the allograft dermal implant.

机译：外部束辐射对同种异体真皮植入物的影响。

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摘要

OBJECTIVE: The purpose of this study was to define the effects of external beam radiation (EBR) on AlloDerm (LifeCell Corp) through the analysis of graft thickness, fibroblast recellularization, and neovascularization as a function of time. METHODS AND MATERIAL: Thirty-six male Sprague-Dawley rats (n = 36) were randomly assigned to 1 of 4 groups (A, B, C, and D). AlloDerm was implanted subcutaneously into the hind legs of each rat, and 20 Gy of EBR was administered to one side. Grafts harvested 1, 2, 4, and 12 weeks after radiation were subjected to blinded histologic analysis. RESULTS: In groups A, B, and C, the irradiated grafts showed a significant decrease in recellularization versus nonirradiated (P < 0.001). At 12 weeks (group D), recellularization equalized, but neovascularization was significantly less (P = 0.048) in the irradiated group. Graft thickness was unaffected. CONCLUSIONS: In the rat model, EBR of the implanted AlloDerm graft hinders recellularization in the early posttreatment period. However, EBR did not adversely affect graft thickness, recellularization or ultimate graft survival.
机译：目的：本研究的目的是通过分析随时间变化的移植物厚度，成纤维细胞再细胞化和新血管形成来定义外部束辐射（EBR）对AlloDerm（LifeCell Corp）的影响。方法和材料：36只Sprague-Dawley雄性大鼠（n = 36）被随机分为4组（A，B，C和D）中的1组。将同种异体真皮皮下植入每只大鼠的后腿，并向一侧施用20 Gy EBR。放疗后1、2、4和12周收集的移植物进行盲法组织学分析。结果：在A，B和C组中，受辐照的移植物与未辐照的相比，其细胞的再细胞化显着减少（P <0.001）。在第12周时（D组），细胞重新形成细胞均等，但在受辐照的组中，新血管形成明显减少（P = 0.048）。接枝厚度不受影响。结论：在大鼠模型中，植入的同种异体真皮移植物的EBR会在后处理初期阻碍细胞的再细胞化。但是，EBR并没有不利地影响移植物的厚度，再细胞化或最终的移植物存活。

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