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首页> 外文期刊>Otolaryngology--head and neck surgery: official journal of American Academy of Otolaryngology-Head and Neck Surgery >Head and neck squamous cell carcinoma: better to be young.
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Head and neck squamous cell carcinoma: better to be young.

机译：头颈部鳞状细胞癌：最好年轻。

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摘要

Most head and neck squamous cell carcinoma patients are elderly, with few younger than 40 years. Controversy exists in the literature regarding outcomes for younger patients. The goal of this research project was to compare baseline features and outcomes for young patients (/=65 years). To investigate the relationship between age and important presenting features and outcomes, 1160 recently diagnosed patients first treated at Washington University between 1980 and 1991 were identified from an existing database. Full 5-year survival information was available for 1030 patients (89%). Overall, the 5-year survival rate was 46% (478/1030); young patients (65%, 26/40) had a significantly better survival rate than middle-aged (52%, 292/566) or old patients (38%, 160/424) (chi(2) = 24.5; P = 0. 001). Survival was also related to smoking, comorbidity, primary site, TNM stage, and nodal disease. Age remained a significant factor even after we controlled for these other factors. Young patients developed fewer recurrent and new primary tumors. We conclude that young patients have a much better overall prognosis than older patients. The reasons for this difference are unclear, but it appears that the impact of age goes beyond an actuarial effect.
机译：大多数头颈部鳞状细胞癌患者是年老的，只有不到40岁。关于年轻患者结局的文献中存在争议。该研究项目的目的是比较年轻患者（ / = 65岁）的基线特征和预后。为了研究年龄与重要表现特征和结局之间的关系，从现有数据库中识别出1980年至1991年间首次在华盛顿大学接受治疗的1160名最近诊断出的患者。 1030名患者（89％）可获得完整的5年生存信息。总体而言，五年生存率为46％（478/1030）;年轻患者（65％，26/40）的存活率明显高于中年（52％，292/566）或老年患者（38％，160/424）（chi（2）= 24.5; P = 0 001）。生存还与吸烟，合并症，原发部位，TNM分期和淋巴结疾病有关。即使我们控制了其他因素，年龄仍然是一个重要因素。年轻患者的复发和新发原发肿瘤更少。我们得出的结论是，年轻患者的总体预后要比老年患者好得多。这种差异的原因尚不清楚，但似乎年龄的影响超出了精算作用。

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