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首页> 外文期刊>Otolaryngology--head and neck surgery: official journal of American Academy of Otolaryngology-Head and Neck Surgery >Hyperbaric compression in the guinea pig with perilymph fistula.
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Hyperbaric compression in the guinea pig with perilymph fistula.

机译：豚鼠周围淋巴瘘管高压加压。

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摘要

OBJECTIVE: The study goal was to evaluate the effects of hyperbaric therapy on the auditory and vestibular function of guinea pigs compromised by perilymph fistula (PLF). METHODS: Twenty-four pigmented guinea pigs underwent induction of bilateral eustachian tube dysfunction before the creation of a unilateral PLF. Half of the animals were randomly assigned to receive immediate hyperbaric compression treatment of 4 "dives" each. Hearing was tested electrocochleographically, and signs of vestibulopathy were recorded before and after compression. RESULTS: After accounting for the effects of PLF, compression was not associated with significant hearing loss (P = 0.5411). Vestibulopathy was seen only in ears with PLF, and its incidence was similar for compression and noncompression groups. CONCLUSION: Hyperbaric compression does not compromise auditory or vestibular function in guinea pig ears with experimental PLF. SIGNIFICANCE: Our observations support the relative safety of recompression in patients with PLF.
机译：目的：研究高压疗法对被淋巴瘘管（PLF）损害的豚鼠的听觉和前庭功能的影响。方法：24只有色豚鼠在诱发单侧PLF前经历了双侧咽鼓管功能障碍。一半动物被随机分配接受高压降压治疗，每只4个“ divs”。通过耳蜗电图检查听力，并在压缩前后记录前庭病的体征。结果：在考虑了PLF的影响后，压迫与明显的听力损失无关（P = 0.5411）。仅在PLF的耳朵中可以看到眼皮病，对于压缩和非压缩组，其发生率相似。结论高压加压不会损害实验性PLF对豚鼠耳朵的听觉或前庭功能。意义：我们的观察结果支持PLF患者再压缩的相对安全性。

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