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首页> 外文期刊>Otolaryngology--head and neck surgery: official journal of American Academy of Otolaryngology-Head and Neck Surgery >Levodopa does not enhance the effect of low-frequency repetitive transcranial magnetic stimulation in tinnitus treatment.
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Levodopa does not enhance the effect of low-frequency repetitive transcranial magnetic stimulation in tinnitus treatment.

机译：左旋多巴在耳鸣治疗中并未增强低频重复经颅磁刺激的效果。

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OBJECTIVE: Low-frequency repetitive transcranial magnetic stimulation (rTMS) has shown promise for the treatment of tinnitus. Experimental data from motor cortex stimulation in healthy subjects indicate that the suppressing effect of low-frequency rTMS can be enhanced by dopaminergic receptor activation. Here we investigated whether administration of the dopamine precursor levodopa before low-frequency rTMS enhances its efficacy in tinnitus treatment. STUDY DESIGN: Sixteen patients with chronic tinnitus received 100 mg of levodopa before each session of low-frequency rTMS. Results were compared with a matched control group of 16 patients who received the same treatment, but without levodopa. Treatment outcome was assessed with a standardized tinnitus questionnaire. RESULTS: Both stimulation protocols resulted in a significant reduction of tinnitus scores after 10 days of stimulation; however, there was no significant difference between the two groups. CONCLUSION: Our data suggest that 100 mg of levodopa does not enhance the effect of rTMS in the treatment of tinnitus.
机译：目的：低频重复经颅磁刺激（rTMS）显示出治疗耳鸣的希望。来自健康受试者的运动皮层刺激的实验数据表明，多巴胺能受体激活可以增强低频rTMS的抑制作用。在这里，我们研究了在低频rTMS之前给予多巴胺前体左旋多巴是否可增强其在耳鸣治疗中的功效。研究设计：16例慢性耳鸣患者在每次低频rTMS治疗前接受了100 mg左旋多巴。将结果与16例接受相同治疗但未使用左旋多巴的患者的对照组进行比较。用标准化的耳鸣问卷评估治疗结果。结果：两种刺激方案均导致刺激10天后耳鸣评分显着降低。但是，两组之间没有显着差异。结论：我们的数据表明，左旋多巴100 mg不能增强rTMS在耳鸣治疗中的作用。

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