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首页> 外文期刊>Otolaryngology--head and neck surgery: official journal of American Academy of Otolaryngology-Head and Neck Surgery >Does surgery improve the survival of patients with advanced anaplastic thyroid carcinoma?
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Does surgery improve the survival of patients with advanced anaplastic thyroid carcinoma?

机译：手术是否可以改善晚期变性甲状腺癌患者的生存率？

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摘要

Anaplastic thyroid carcinoma is one of the most lethal neoplasms, with poor prognosis being reported by most authors. The benefits of surgery for most cases of advanced disease remain controversial. In this study we asked the following question: Does surgical intervention alter outcomes for patients with advanced anaplastic thyroid carcinoma? Forty-six patients with advanced anaplastic thyroid carcinoma were analyzed. There were 20 patients with advanced localized disease (group 1), 15 of whom received surgery. Of the other 26 patients with evidence of distant metastases (group 2), 13 received surgery. For group 1 patients, the mean survival was 12.8 months versus 8.6 months in the surgical and nonsurgical subgroups (p = 0.46). For group 2 patients, the mean survival was 3.5 months versus 2.8 months in the surgical and nonsurgical subgroups (p = 0.72). These data suggest that surgery does not improve survival for patients with advanced anaplastic thyroid carcinoma. In conclusion, the mean survival showed no significant differences between surgical and nonsurgical patients (p = 0.43). This study suggests that surgical resection does not improve the survival of patients with advanced anaplastic thyroid carcinoma.
机译：间变性甲状腺癌是最致命的肿瘤之一，多数作者预后不良。对于大多数晚期疾病，手术的益处仍然存在争议。在这项研究中，我们提出了以下问题：外科手术是否会改变晚期变性甲状腺癌患者的预后？分析了46例晚期间变性甲状腺癌患者。有20位晚期局部疾病患者（第1组），其中15位接受了手术。在其他26例有远处转移迹象的患者中（第2组），其中13例接受了手术。对于第1组患者，平均生存期为12.8个月，而手术和非手术亚组的平均生存期为8.6个月（p = 0.46）。对于第2组患者，平均生存期为3.5个月，而手术和非手术亚组为2.8个月（p = 0.72）。这些数据表明，手术不能改善晚期变性甲状腺癌患者的生存率。总之，手术和非手术患者的平均生存率无显着差异（p = 0.43）。这项研究表明，手术切除不能改善晚期变性甲状腺癌患者的生存率。

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