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首页> 外文期刊>Otolaryngology--head and neck surgery: official journal of American Academy of Otolaryngology-Head and Neck Surgery >Early-response cytokine expression in adult middle ear effusions.
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Early-response cytokine expression in adult middle ear effusions.

机译：成人中耳积液中的早期反应细胞因子表达。

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摘要

Various cytokines are presently known to be associated with the regulation of inflammatory responses. In pediatric otitis media, cytokines that correlate with various degrees of inflammation are present in middle ear effusions as inflammatory mediators. The present study was undertaken to examine the potential role of the early-response cytokines, interleukin-1beta and tumor necrosis factor-alpha, in adult otitis media. Fifty-nine adults with otitis media underwent tympanocentesis, and the effusion specimens were analyzed for the presence of both cytokines by enzyme-linked immunosorbent assay methods. Eighty-eight percent of the effusions were serous in nature. Sixty-seven percent of the patients had a known history of head and neck malignancy and radiation to the temporal bone. Twelve percent of the effusions were positive for interleukin-1beta expression, compared with 85% of effusions in children with otitis media. Eight percent of the effusions contained tumor necrosis factor-alpha, compared with 85% of those collected in pediatric otitis media. All of the specimens that contained tumor necrosis factor-alpha also contained interleukin-1beta. In the present study, there was no correlation with head and neck malignancy/radiation or the clinical degree of inflammation with the presence of either cytokine. We conclude that adult otitis media is associated with lower expression of an acute inflammatory response, as judged by the levels of interleukin-1beta and tumor necrosis factor-alpha in the effusions. Additionally, adult otitis probably represents a less severe and more chronic inflammatory state in comparison with pediatric otitis media. Further analysis of inflammatory mediators in adult otitis media is necessary to evaluate the contribution of cytokines in relation to various etiologic factors.
机译：目前已知多种细胞因子与炎症反应的调节有关。在小儿中耳炎中，中耳积液中存在与炎症程度不同相关的细胞因子作为炎症介质。本研究旨在检查早期反应性细胞因子白细胞介素-1β和肿瘤坏死因子-α在成人中耳炎中的潜在作用。五十九名患有中耳炎的成年人进行了鼓膜穿刺术，并通过酶联免疫吸附法对渗出样品中两种细胞因子的存在进行了分析。 88％的积液本质上是浆液性的。 67％的患者有头颈恶性肿瘤和颞骨放射史。 12％的积液对白介素-1β表达呈阳性，而中耳炎儿童的积液为85％。 8％的积液含有肿瘤坏死因子-α，而在小儿中耳炎中则积聚了85％。所有包含肿瘤坏死因子-α的标本也包含白介素-1β。在本研究中，与任何一种细胞因子的存在均与头颈部恶性肿瘤/放射线或炎症的临床程度无关。我们得出的结论是，根据积液中白介素-1β和肿瘤坏死因子-α的水平判断，成人中耳炎与急性炎症反应的较低表达有关。另外，与小儿中耳炎相比，成年中耳炎可能代表的是一种较轻的，较慢性的炎症状态。对成年中耳炎中炎性介质的进一步分析对于评估细胞因子与各种病因相关的贡献是必要的。

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