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首页> 外文期刊>Otolaryngology--head and neck surgery: official journal of American Academy of Otolaryngology-Head and Neck Surgery >Polarization-sensitive optical coherence tomography imaging of benign and malignant laryngeal lesions: an in vivo study.
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Polarization-sensitive optical coherence tomography imaging of benign and malignant laryngeal lesions: an in vivo study.

机译：良性和恶性喉病变的偏振敏感光学相干断层扫描成像：一项体内研究。

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OBJECTIVE: Optical coherence tomography (OCT), an imaging technology that provides cross-sectional subsurface tissue structure images using back-scattered light, is a promising noninvasive imaging modality for in vivo assessment of vocal fold layered microstructure. Polarization-sensitive OCT (PS-OCT) augments conventional OCT by detecting changes in the polarization state of reflected light. This study imaged various benign and malignant laryngeal pathologies in patients undergoing direct laryngoscopy under general anesthesia to determine whether PS-OCT would provide useful additional information about vocal fold microstructure and glottic surface pathology. STUDY DESIGN. Prospective clinical trial. SETTING: Tertiary care center. SUBJECTS AND METHODS: Twenty-three patients who were undergoing microlaryngoscopy under general anesthesia for benign (n = 18) and alignant (n = 5) glottic disease were imaged bilaterally with OCT and PS-OCT (n = 46 vocal folds). Intraoperative microphotography guided placement of the imaging probe. Normal-appearing glottic tissue was also imaged if present. When clinically indicated, biopsy or complete removal of the lesion established histologic confirmation. RESULTS: PS-OCT provided high-quality, vertical, cross-sectional images up to 1.2-mm deep that complemented microlaryngoscopy and conventional OCT for vocal fold pathologies. Scar tissue was visualized by PS-OCT, characterized by a birefringence pattern more intense than that of normal glottic tissue. Cancer typically showed disruption or absence of both layered structure and birefringence. CONCLUSION: Combining PS-OCT with OCT during human vocal cord imaging provides useful information in characterizing vocal cord lesions, articularly scar tissue.
机译：目的：光学相干断层扫描（OCT）是一种使用背向散射光提供横断面亚表面组织结构图像的成像技术，是一种用于体内评估声带分层微结构的有前途的无创成像方法。偏振敏感型OCT（PS-OCT）通过检测反射光的偏振态变化来增强传统的OCT。这项研究对全麻下接受直接喉镜检查的患者的各种良性和恶性喉部病理学进行了成像，以确定PS-OCT是否会提供有关声带微结构和声门表面病理学的有用附加信息。学习规划。前瞻性临床试验。地点：三级护理中心。研究对象和方法：对二十三名因良性（n = 18）和恶性（n = 5）声门病变在全身麻醉下进行微喉镜检查的患者，使用OCT和PS-OCT（n = 46声带）进行双侧影像学检查。术中显微照相术指导成像探头的放置。如果存在，正常出现的声门组织也会成像。当临床上有指征时，活检或完全清除病灶可建立组织学证实。结果：PS-OCT提供了高达1.2毫米深的高质量，垂直，横截面图像，是微喉镜和常规OCT的声带病理学的补充。疤痕组织通过PS-OCT可视化，其特征是双折射模式比正常声门组织更强烈。癌症通常表现出层状结构和双折射的破坏或缺失。结论：在人声带成像期间将PS-OCT与OCT结合使用可为表征声带病变（尤其是瘢痕组织）提供有用的信息。

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