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首页> 外文期刊>Saudi medical journal. >Study on related indexes of the coagulation and fibrinolytic system after renal ischemia reperfusion injury in Wistar rats
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Study on related indexes of the coagulation and fibrinolytic system after renal ischemia reperfusion injury in Wistar rats

机译：Wistar大鼠肾脏缺血再灌注损伤后凝血与纤溶系统相关指标的研究

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Objectives: To explore changes in indicators of the coagulation and fibrinolytic system in the serum of rats with renal ischemia reperfusion (IR) injury. Methods: The study was carried out at the Nephrology Laboratory of the Second Hospital, Shanxi Medical University, Taiyuan, China between September and October 2012. A rat renal IR model was established, Articles and serum samples of each group (8 each) were collected to detect the amounts of fibrinogen (FIB), antithrombin III (AT-III), tissue type plasminogen activator (tPA), plasminogen-antiplasmin complex (PAP), and plasminogen activator inhibitor-1 (PAI-1). Results: After the start of reperfusion, the changes of FIB exhibited a "double-peak" appearance. The AT-III began to decline at 2 hours to the lowest level at 12 hours, and then gradually recovered. The tPA declined to the lowest level at 12 hours, and then increased to the highest level at 24 hours. The PAI-1 began to increase at 6 hours, and peaked at 24 hours, and then recovered gradually. The PAP peaked at 6 hours, and declined to the lowest level at 12 hours, and began to recover at 24 hours, and was normal at 36 hours. All the above indexes were completely restored at 48 hours. Conclusion: At 2 hours after reperfusion, the coagulation system were activated, reaching a peak at 12 hours. Fibrinolytic and antifibrinolytic substances were activated at 2 hours, and the fibrinolytic system was inhibited at 6 hours, reaching a peak at 24 hours. Coagulation and fibrinolytic substances were restored to normal at 48 hours.
机译：目的：探讨肾缺血再灌注（IR）大鼠血清凝血和纤溶系统指标的变化。方法：本研究于2012年9月至10月在太原山西医科大学第二医院肾内科实验室进行。建立大鼠肾脏IR模型，收集每组8只的文章和血清样本。检测纤维蛋白原（FIB），抗凝血酶III（AT-III），组织型纤溶酶原激活物（tPA），纤溶酶原-抗纤溶酶复合物（PAP）和纤溶酶原激活物抑制剂1（PAI-1）的量。结果：再灌注开始后，FIB的变化呈现出“双峰”外观。 AT-III在2小时开始下降到12小时的最低水平，然后逐渐恢复。 tPA在12小时下降到最低水平，然后在24小时上升到最高水平。 PAI-1在6小时开始增加，并在24小时达到峰值，然后逐渐恢复。 PAP在6小时达到峰值，并在12小时降至最低水平，并在24小时开始恢复，在36小时时恢复正常。以上所有指标均在48小时后完全恢复。结论：再灌注后2小时，凝血系统被激活，并在12小时达到峰值。纤溶和抗纤溶物质在2小时被激活，纤溶系统在6小时被抑制，在24小时达到峰值。凝血和纤溶物质在48小时后恢复正常。

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