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首页> 外文期刊>Scandinavian journal of plastic and reconstructive surgery and hand surgery >Effects of clopidogrel and high dose aspirin on survival of skin flaps in rats.
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Effects of clopidogrel and high dose aspirin on survival of skin flaps in rats.

机译：氯吡格雷和大剂量阿司匹林对大鼠皮瓣存活的影响。

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Clopidogrel is a new antiplatelet agent with a different mechanism of action from aspirin. It is thienopyridine derivative that is chemically related to ticlopidine, which irreversibly inhibits platelet aggregation by selectively binding to adenylate-cyclase-coupled adenosine diphosphate receptors on the platelet's surface. Aspirin is an antiplatelet agent that acetylates cyclo-oxygenase and decreases the products of arachidonic acid metabolism, including thromboxane and prostacyclin. Necrosis of a flap is still an important complication in reconstructive surgery. To investigate the effects of clopidogrel or high dose aspirin on the survival of skin flaps, 30 rats were divided into three groups of 10 animals each: a control group, a clopidogrel group, and a high-dose aspirin group. No pharmacological agents were used in the control group. Of the two treated groups, the first was given clopidogrel 50 mg/kg/day and the second aspirin 200 mg/kg/day for three days before the operation. After seven days theviable areas of each flap were evaluated and the mean (SD) percentage in the control group was 47 (6), in the clopidogrel group 63 (4), and in the aspirin group 65 (5). Although the mean area of flaps that survived in the aspirin group was slightly higher than in the clopidogrel group, the difference was not significant (p = 0.54).
机译：氯吡格雷是一种新型抗血小板药，其作用机理与阿司匹林不同。它是噻吩并吡啶衍生物，与噻氯匹定在化学上相关，它通过选择性结合血小板表面腺苷酸-环化酶偶联的腺苷二磷酸受体，不可逆地抑制血小板凝集。阿司匹林是一种抗血小板药，可乙酰化环加氧酶并减少花生四烯酸代谢产物，包括血栓烷和前列环素。皮瓣坏死仍是重建手术中的重要并发症。为了研究氯吡格雷或大剂量阿司匹林对皮瓣存活的影响，将30只大鼠分为三组，每组10只动物：对照组，氯吡格雷组和大剂量阿司匹林组。对照组中未使用任何药物。在两个治疗组中，第一组在手术前三天给予氯吡格雷50 mg / kg /天，第二组阿司匹林200 mg / kg /天。 7天后，评估每个皮瓣的存活面积，对照组的平均（SD）百分比为47（6），氯吡格雷组为63（4），阿司匹林组为65（5）。尽管阿司匹林组存活的皮瓣平均面积略高于氯吡格雷组，但差异无统计学意义（p = 0.54）。

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