An Improved and Scalable Process for Zafirlukast: An Asthma Drug

Gilla Goverdhan; Anumula Raghupathi Reddy; Aalla Sampath

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An Improved and Scalable Process for Zafirlukast: An Asthma Drug

机译：Zafirlukast的改进和可扩展过程：哮喘药物

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摘要

An improved and scalable process for the large-scale production of zafirlukast (Accolate), an important drug for asthma, is discussed along with impurity and scale-up-related issues.

机译：讨论了一种重要的治疗哮喘的重要药物扎鲁司特（醋酸盐）的大规模生产改进方法以及与杂质和放大相关的问题。

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《Organic process research & development》 |2009年第1期|共6页
作者
Gilla Goverdhan; Anumula Raghupathi Reddy; Aalla Sampath;
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正文语种 eng
中图分类有机化学;
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1. An Improved and Scalable Process for Zafirlukast: An Asthma Drug [J] . Gilla Goverdhan, Anumula Raghupathi Reddy, Aalla Sampath Organic process research & development . 2009,第1期

机译：Zafirlukast的改进和可扩展过程：哮喘药物
2. An Improved and Scalable Process for the Synthesis of 5-Azacytidine: An Antineoplastic Drug [J] . Satish Kumar Vujjini, Ganesh Varanasi, Srinivas Arevelli Organic process research & development . 2013,第2期

机译：一种改进的可扩展的合成5-氮杂胞苷的方法：一种抗肿瘤药物。
3. An improved and scalable process for the synthesis of a key intermediate for Etodolac, a non-steroidal anti-inflammatory drug [J] . M Chandra Sekharayya, G Venkata Narayana Indian Journal of Chemistry, Section B. Organic Including Medicinal . 2012,第12期

机译：一种改进的，可扩展的方法，用于合成非甾体类抗炎药依托度酸的关键中间体
4. SUPERCRITICAL CO_2 ANTISOLVENT PROCESS FOR DRUGS PRECIPITATION: FROM LAB-SCALE TO cGMP COMPLIANT PILOT-SCALE [C] . S. Papet, F, Marciacq, International Symposium on Supercritical Fluids Tome 3: Materials Processing; 20030428-20030430; Versailles; FR . 2003

机译：药物沉淀的超临界CO_2抗溶过程：从实验室规模到符合cGMP的中试规模
5. Scalable Compiler Optimizations for Improving the Memory System Performance in Multi- and Many-core Processors. [D] . Mehta, Sanyam. 2014

机译：可扩展的编译器优化，用于提高多核和多核处理器中的内存系统性能。
6. Health And Drug Alerts: Asthma drug zafirlukast (Accolate): serious hepatic events [O] . Eric Wooltorton 2004

机译：健康和药物警报：哮喘药物扎鲁司特（醋酸盐）：严重的肝病
7. Synthesis and characterization of critical process related impurities of an asthma drug – Zafirlukast [O] . Gilla Goverdhan, Anumula Raghupathi Reddy, Vurimidi Himabindu, 2014

机译：哮喘药物 - 扎鲁司特的关键过程相关杂质的合成与表征

An Improved and Scalable Process for Zafirlukast: An Asthma Drug

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