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A Cheap, Easy Microfluidic Crystallization Device Ensuring Universal Solvent Compatibility

机译:便宜,容易的微流体结晶装置,可确保通用溶剂的兼容性

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摘要

Microfluidic devices are increasingly used for the screening of crystallization conditions. Their advantage is the generation of droplets, every droplet being an independent crystallizer with volumes in the nanoliter range. This enables a large number of experiments to be carried out under identical conditions necessitating only small quantities of materials. However, classic microfluidic crystallization devices are made of poly(dimethylsiloxane), only compatible with an aqueous medium. In addition, they generally involve very complicated setups, often inaccessible to nonmicrofluidics specialists. In this paper, we overcome these drawbacks, presenting a cheap and universally applicable microfluidic crystallization tool. This thermostatted device makes it possible to study nucleation in both aqueous and organic solvents, rendering microfluidic devices applicable to organic molecules such as APIs, explosives, and metal oxide nanoparticles.
机译:微流体装置越来越多地用于筛选结晶条件。它们的优点是产生液滴,每个液滴都是体积在纳升范围内的独立结晶器。这样就可以在相同条件下进行大量实验,只需要少量的材料。然而,经典的微流体结晶装置是由聚二甲基硅氧烷制成的,仅与水性介质相容。此外,它们通常涉及非常复杂的设置,通常是非微流体专家无法访问的。在本文中,我们克服了这些缺点,提出了一种便宜且普遍适用的微流体结晶工具。这种恒温设备使研究水性和有机溶剂中的成核成为可能,从而使微流体设备适用于有机分子,如API,炸药和金属氧化物纳米颗粒。

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