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Register-based studies of cardiovascular disease

机译：基于登记的心血管疾病研究

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Introduction: The use of the unique personal identification number in the Nordic database systems enables the researchers to link the registers at the individual level. The registers can be used for both defining specific patient populations and to identify later events during follow-up. This review gives three examples within cardiovascular epidemiology to illustrate the use of the national administrative registers available to all researchers upon request. Research topics: The hospitalisation rate of acute myocardial infarction (AMI) was expected to be increased and case-fatality rate to decrease when the diagnostic criteria were changed in 2000. Linkage of national registers found a relative increase in hospitalisation rate of 14% while the case-fatality rate was unaffected. The pharmacological treatment of AMI patients was evaluated by linkage of administrative data. The use of evidence-based treatment increased significantly over time and adherence to treatment was high. Finally, use of specific nonsteroidal antiinflammatory drugs by healthy subjects was associated with a dose-dependent increase in cardiovascular risk. Conclusion: The nationwide registers have proven very useful in monitoring the hospitalisation rate and treatment of cardiovascular disease. The risk of unmeasured factors affecting the results calls for cautious interpretation of the results.
机译：简介：在北欧数据库系统中使用唯一的个人识别号码，使研究人员可以在各个级别上链接寄存器。寄存器可用于定义特定的患者人群并在随访期间识别以后的事件。这篇综述给出了心血管流行病学中的三个例子，以说明应要求向所有研究人员提供的国家行政登记册的使用。研究主题：2000年，当诊断标准改变时，急性心肌梗死（AMI）的住院率有望提高，病死率降低。国家注册机构的联系发现住院率相对增加了14％，而病死率不受影响。通过管理数据的链接来评估AMI患者的药物治疗。随着时间的推移，循证治疗的使用显着增加，并且对治疗的依从性很高。最后，健康受试者使用特定的非甾体类抗炎药与心血管风险的剂量依赖性增加有关。结论：全国范围内的登记证明对监测心血管疾病的住院率和治疗非常有用。影响结果的不可估量因素的风险要求对结果进行谨慎的解释。

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