Lethal phenotype of mice carrying a Sept11 null mutation.

Roseler S; Sandrock K; Bartsch I; Busse A; Omran H; Loges NT; Zieger B

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Lethal phenotype of mice carrying a Sept11 null mutation.

机译：携带Sept11无效突变的小鼠的致死表型。

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Septins are cytoskeletal GTP-binding proteins involved in processes characterized by active membrane movement, such as cytokinesis, vesicle trafficking and exocytosis. Most septins are expressed ubiquitously, however, some septins accumulate in particular tissues. The ubiquitous SEPT11 also shows high expression levels in the central nervous system and in platelets. Here, SEPT11 is involved in vesicle trafficking and may play a role in synaptic connectivity. Interestingly, mice that harbor a homozygous Sept11 null mutation, die in utero. From day 11.5 post coitum onwards, development of homozygous embryos seems to be retarded and the embryos from day 13.5 onwards were dead.

机译：Septins是细胞骨架GTP结合蛋白，参与以活动膜移动为特征的过程，例如胞质分裂，囊泡运输和胞吐作用。大多数Septins普遍存在，但是某些Septins会在特定组织中积累。普遍存在的SEPT11在中枢神经系统和血小板中也显示出高表达水平。在这里，SEPT11参与囊泡运输，并可能在突触连接中发挥作用。有趣的是，带有纯合的Sept11无效突变的小鼠在子宫内死亡。从交配后第11.5天起，纯合子胚胎的发育似乎受阻，从第13.5天起死去的胚胎。

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《Biological chemistry》 |2011年第9期|共3页
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Roseler S; Sandrock K; Bartsch I; Busse A; Omran H; Loges NT; Zieger B;
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中图分类生物化学;
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1. Lethal phenotype of mice carrying a Sept11 null mutation. [J] . Roseler S, Sandrock K, Bartsch I, Biological chemistry . 2011,第8a9期

机译：携带Sept11无效突变的小鼠的致死表型。
2. Peri-implantation lethality in mice carrying megabase-scale deletion on 5qc3.3 is caused by Exoc1 null mutation [J] . Seiya Mizuno, Kohei Takami, Yoko Daitoku, Scientific reports. . 2015,第1期

机译：Exoc1无效突变导致5qc3.3上百万碱基级缺失的小鼠的围着床致死率
3. ENDOCRINE EXPRESSION OF THE ACTIVE FORM OF TGF-beta1 IN THE TGF-beta1 NULL MICE FAILS TO AMELIORATE LETHAL PHENOTYPE. [J] . Longenecker G, Thyagarajan T, Nagineni CN, Cytokine . 2002,第1期

机译：TGF-beta1空小鼠中TGF-beta1活性形式的内分泌表达未能改善LETHAL表型。
4. Mitigating dystrophic calcification of bovine pericardium by osteopontin (– rescuing the calcification phenotype in osteopontin-null mice) [C] . Rachit Ohri, Cecilia M. Giachelli Annual meeting of the Society For Biomaterials . 2002

机译：骨桥蛋白减轻牛心包的营养不良性钙化（–挽救无骨桥蛋白的小鼠的钙化表型）
5. Longitudinal characterization of the mesenchymal progenitor cell phenotype of Sca-1/Ly6A null mice. [D] . Holmes, Christina. 2006

机译：Sca-1 / Ly6A缺失小鼠的间充质祖细胞表型的纵向表征。
6. Peri-implantation lethality in mice carrying megabase-scale deletion on 5qc3.3 is caused by Exoc1 null mutation [O] . Seiya Mizuno, Kohei Takami, Yoko Daitoku, -1

机译：Exoc1无效突变引起5qc3.3上百万碱基级缺失的小鼠的围着床致死率
7. Peri-implantation lethality in mice carrying megabase-scale deletion on 5qc3.3 is caused by Exoc1 null mutation [O] . Mizuno Seiya, Takami Kohei, Daitoku Yoko, 2015

机译：Exoc1无效突变引起5qc3.3上百万碱基级缺失的小鼠的围着床致死率
8. Disruption of NBS1 gene leads to early embryonic lethality in homozygous null mice and induces specific cancer in heterozygous mice [R] . 2002

机译：NBs1基因的破坏导致纯合无效小鼠的早期胚胎致死率并诱导杂合小鼠中的特定癌症

Lethal phenotype of mice carrying a Sept11 null mutation.

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