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首页> 外文期刊>Cell and tissue banking: An international journal of banking, engineering & transplantation of cells and tissues >Should Deceased Donors be Tested for vCJD?
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Should Deceased Donors be Tested for vCJD?

机译：死者应该接受vCJD测试吗？

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The 1997 Bovine Spongiform Encephalopathy enquiry and the 2001 Hepatitis C litigation judgement set the UK scene for evoking the precautionary principle and the legal precedent that liability for defective transfusion products should not be dependent on medical negligence, but on the mere fact of defectiveness. Animal models indicate that vCJD in humans, with infection via the oral route, is likely to be associated with infectivity within the lymphoreticular system (LRS). This is likely to appear prior to the involvement of the central nervous system and thus infectivity is likely to be present in the LRS before the onset of clinical disease. A number of relevant epidemiological studies using LRS tissue have shown a low, but measurable, existence of the carrier state in vCJD. Two possible cases of transmission of the abnormal prion of vCJD by blood transfusion suggested that tissues might also transmit and that testing of LRS tissue from deceased potential tissue donors should be considered as a first measure towards the prevention of vCJD transmission by tissues designated for use in transplantation. A variety of different tissues could be used as representative of the LRS, but each is associated with problems of feasibility and practicality. Assays for vCJD have not been validated in the context of donor screening rather than epidemiological studies nor on deceased donors. However, given the number of vCJD cases in the UK, significant attention should be paid to the logistical, ethical, social and other issues associated with undertaking vCJD testing of tissue donors, with a view to introducing testing of deceased tissue donors for vCJD disease or latency.
机译：1997年的牛海绵状脑病调查和2001年的C型肝炎诉讼判决为英国提倡了预防原则和法律上的先例，即对有缺陷的输血产品的赔偿责任不应取决于医疗过失，而仅取决于缺陷的事实。动物模型表明，人类vCJD通过口服途径感染，很可能与淋巴网状系统（LRS）的感染性有关。这很可能出现在中枢神经系统受累之前，因此，在临床疾病发作之前，LRS可能存在感染性。使用LRS组织进行的许多相关流行病学研究表明，vCJD中携带者状态的存在率低但可测量。通过输血传播vCJD异常病毒的两种可能情况表明，组织也可能会传播，应考虑对已故潜在组织供体的LRS组织进行检测是预防指定用于组织的vCJD传播的首要措施移植。各种不同的组织可以用作LRS的代表，但是每种组织都存在可行性和实用性问题。对vCJD的检测尚未在捐赠者筛查的背景下进行验证，而不是在流行病学研究或已故的捐赠者中得到验证。但是，鉴于英国的vCJD病例数，应特别注意与进行组织捐献者的vCJD检测有关的后勤，道德，社会和其他问题，以期对已故的组织捐献者进行vCJD疾病或潜伏。

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