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首页> 外文期刊>Cell and tissue banking: An international journal of banking, engineering & transplantation of cells and tissues >Bone Regeneration Using rhBMP-2 Induction in Hemimandibulectomy Type Defects of Elderly Sub-Human Primates
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Bone Regeneration Using rhBMP-2 Induction in Hemimandibulectomy Type Defects of Elderly Sub-Human Primates

机译：使用rhBMP-2诱导的老年人亚人类灵长类动物的半髋切除术类型的骨再生

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Our previous work has shown that total osseous reconstruction of large discontinuity hemimandibulectomy, critical-sized defects can be achieved easily in 8-year-old Macaca fascicularis monkeys (Boyne 1996). However the literature has indicated that animal aging decreases the BMP induction of stem cells in rats and in other rodent species. It was necessarily important that the rhBMP-2 be demonstrated in non-human primates to determine if this reduction in effectiveness also existed in the higher animals phylogenetically. The purpose of this study was to operate aged non-human primates duplicating the model used in middle-aged animals to demonstrate regeneration of hemimandibulectomy defects. This age group could be extrapolated to the 80-year-old clinic patient. Six non-human primates aged 20 years were rendered edentulous posteriorly and the mandibles allowed to heal. Three months postoperatively bilateral hemimandibulectomies were performed. The defects received BMP in a collagen sponge (Helistat) using a dose level of 0.75 mg of rhBMP-2. After the manner previously reported by Boyne (1996, 1999), at the end of four months the surgical sites were exposed by mucoperiosteal flap demonstrating complete regeneration of the critical-sized defects. The animals received two dental implants in restored areas. The implants were brought into function approximately four months later, and were allowed to function for eight months in all cases. The results indicate that the regeneration of mandibular critical-sized defects by the use of rhBMP-2 in aged animals is comparable to that of the middle-aged group. This study indicates that aged non-human primates, chronologically comparable to 80-year-old humans, respond as favorably to rhBMP-2 as do the middle-aged animals. Extrapolating the results to the clinical level, one would expect that rhBMP-2 would produce a comparable result in the regeneration of large hemimandibulectomy-type defects in clinical human patients.
机译：我们以前的工作表明，在8岁大的猕猴猕猴中很容易实现大间断半球形全骨切除的全骨重建，达到临界大小的缺损（Boyne 1996）。但是，文献表明，动物衰老会降低大鼠和其他啮齿动物物种中干细胞的BMP诱导。必须在非人类灵长类动物中证明rhBMP-2，以确定这种有效性的降低是否在系统发育上也存在于高等动物中。这项研究的目的是对年龄较大的非人类灵长类动物进行手术，以复制用于中年动物的模型，以证明半下颌切除术缺损的再生。该年龄组可以推断为80岁的门诊患者。六个年龄20岁的非人类灵长类动物后牙无牙，下颌骨得以愈合。术后三个月进行了双侧半踝切除术。使用0.75 mg rhBMP-2的剂量在胶原蛋白海绵（Helistat）中将缺损接受BMP。按照Boyne（1996，1999）先前报道的方法，在四个月末，手术部位被粘膜骨膜瓣暴露，表明临界大小的缺损已完全再生。这些动物在修复区域接受了两次牙科植入。植入物大约四个月后开始运作，在所有情况下都允许运作八个月。结果表明，在老年动物中通过使用rhBMP-2再生下颌临界大小的缺损与中年组相当。这项研究表明，按时间顺序与80岁的人类相比，年龄较大的非人类灵长类动物对rhBMP-2的反应与中年动物一样好。将结果推算到临床水平，人们会期望rhBMP-2在临床人类患者的大半下颌切除术类型缺损的再生中产生可比的结果。

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