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首页> 外文期刊>Cell and tissue banking: An international journal of banking, engineering & transplantation of cells and tissues >Post-operative infection with fresh frozen allograft: reported outcomes of a hospital-based bone bank over 14 years
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Post-operative infection with fresh frozen allograft: reported outcomes of a hospital-based bone bank over 14 years

机译：新鲜冷冻冷冻同种异体的术后感染：据报道一家医院的骨库在14年内的结果

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Femoral head bone allografts have traditionally been used to provide mechanical stability to areas of bony deficiency, or for its osteoinductive and osteoconductive properties. Concerns have been raised over increased infection rates following the use of fresh-frozen graft tissue. This retrospective study aims to investigate the outcomes of fresh frozen femoral heads kept in a regulated, non-commercial bone bank at a university teaching hospital.The local bone bank database was used to identify released femoral heads during a 14 year study period (September 1999-December 2013) whereby a retrospective review of patient records was undertaken to determine clinical outcome. During the observed study period, 427 femoral heads were released from cold storage. Of these, 270 femoral heads had a mean follow-up of 347 days. 157 femoral heads were excluded due to insufficient follow-up data (n = 132) or discarded due to breaks in the cold chain prior to use (n = 25). Of the 270 included femoral heads, 231 (85.6 %) had no reported complications with good graft incorporation. In the remaining 39 with reported complications, only 5 (2.6 %) developed a postoperative infection. Our findings suggest that the use of fresh frozen allograft does not materially increase the risk of post-operative bacterial infection. Our reported post-operative infection rates are comparable with infection rates of other similar studies on fresh frozen allograft use.
机译：传统上，股骨头同种异体移植已用于为骨缺损区域提供机械稳定性，或具有其骨诱导和骨传导特性。使用新鲜冷冻的移植组织后，感染率上升已引起关注。这项回顾性研究旨在研究保存在一家大学教学医院的非商业性正规骨库中的新鲜冷冻股骨头的结局。在14年的研究期内（1999年9月），使用当地的骨库数据库来识别释放的股骨头-2013年12月），对患者记录进行回顾性检查以确定临床结果。在观察的研究期间，从冷藏库中取出了427个股骨头。其中270例股骨头平均随访347天。由于随访数据不足（n = 132），排除了157个股骨头;或由于使用前冷链断裂（n = 25）而被丢弃。在270例包括股骨头的患者中，没有231例（85.6％）报道过移植物合并良好的并发症。在其余39例报告有并发症的患者中，只有5例（2.6％）发生了术后感染。我们的发现表明，使用新鲜的冷冻同种异体移植物并不会从实质上增加术后细菌感染的风险。我们报道的术后感染率与新鲜冷冻同种异体移植使用的其他类似研究的感染率相当。

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