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首页> 外文期刊>Cell and tissue banking: An international journal of banking, engineering & transplantation of cells and tissues >Long-term result of autologous cultivated oral mucosal epithelial transplantation for severe ocular surface disease
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Long-term result of autologous cultivated oral mucosal epithelial transplantation for severe ocular surface disease

机译：自体口腔黏膜上皮自体培养治疗严重眼表疾病的长期疗效

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The present study aimed to investigate the clinical outcomes of autologous cultivated oral mucosal epithelial transplantation (COMET) on human amniotic membrane (AM) for corneal limbal stem cell deficiency (LSCD). In this prospective, noncomparative case series, 20 eyes (18 patients) with bilateral severe ocular surface disease were chosen to undergo COMET on human AM. The primary outcome was clinical success, and the secondary outcomes were the best-corrected visual acuity difference, corneal opacification, symblepharon formation, and complications. The mean patient age was 48.2 +/- A 15.5 years. The mean follow-up time was 31.9 +/- A 12.1 months (range 8-50 months). All except one eye exhibited complete epithelialization within the first postoperative week. A successful clinical outcome, defined as a stable ocular surface without epithelial defects, a clear cornea without fibrovascular tissue invasion at the pupillary area, and no or mild ocular surface inflammation, was obtained in 15 of 20 eyes (75 %). The clinical success rate at 1 year was 79.3 %, and that at 4 years (end of follow-up) was 70.5 %. Fourteen of 20 (70 %) eyes exhibited improvement in visual acuity after COMET, and some required subsequent cataract surgery (2 eyes), penetrating keratoplasty (3 eyes), or keratoprosthesis implantation (1 eye). Preoperative symblepharon was eliminated in most eyes (8 of 13, 61.5 %) after COMET combined with eyelid reconstruction when needed. The only complication was corneal perforation (1 eye) induced by a severe eyelid abnormality; treatment with a tectonic corneal graft was successful. COMET can successfully restore ocular surface damage in most eyes with corneal LSCD.
机译：本研究旨在探讨自体培养的口腔黏膜上皮移植物（COMET）在人羊膜（AM）上治疗角膜缘干细胞缺乏症（LSCD）的临床效果。在这一前瞻性，非对照病例系列中，选择了20眼（18例）双侧严重眼表疾病对人AM进行COMET。主要结局是临床成功，次要结局是校正最佳的视力差异，角膜混浊，交指形成和并发症。平均患者年龄为48.2 +/- A 15.5岁。平均随访时间为31.9 +/- A 12.1个月（范围8-50个月）。术后第一周内，除一只眼睛外，所有眼睛均完全上皮化。在20眼中有15眼（75％）获得了成功的临床结果，定义为稳定的眼表无上皮缺损，角膜透明无瞳孔区域纤维组织浸润，无或轻度眼表炎症。 1年的临床成功率为79.3％，而4年（随访结束）的临床成功率为70.5％。 20眼中有14眼（70％）在COMET后表现出视力的改善，其中一些需要随后的白内障手术（2眼），穿透性角膜移植术（3眼）或角膜假体植入（1眼）。必要时在COMET联合眼睑重建后，大多数眼睛中没有术前交趾龙（13眼中的8眼，占61.5％）。唯一的并发症是由严重的眼睑异常引起的角膜穿孔（1只眼）。构造角膜移植物治疗成功。 COMET可成功恢复大多数角膜LSCD的眼表损伤。

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