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Evaluation of new antibiotic cocktails against contaminating bacteria found in allograft tissues

机译:评估新型抗生素混合物对异体移植组织中发现的污染细菌的作用

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Contamination of retrieved tissues is a major problem for allograft safety. Consequently, tissue banks have implemented decontamination protocols to eliminate microorganisms from tissues. Despite the widespread adoption of these protocols, few comprehensive studies validating such methods have been published. In this manuscript we compare the bactericidal activity of different antibiotic cocktails at different temperatures against a panel of bacterial species frequently isolated in allograft tissues collected at the Treviso Tissue Bank Foundation, a reference organization of the Veneto Region in Italy that was instituted to select, recover, process, store and distribute human tissues. We were able to identify at least two different formulations capable of killing most of the bacteria during prolonged incubation at 4 A degrees C.
机译:回收组织的污染是同种异体移植安全性的主要问题。因此,组织库已实施去污协议以消除组织中的微生物。尽管这些协议被广泛采用,但很少有验证此类方法的综合研究发表。在本手稿中,我们将不同抗生素混合物在不同温度下的杀菌活性与特雷维索组织银行基金会(意大利威尼托大区的一个参考组织,该组织旨在选择,回收)中经常分离的同种异体移植组织中分离出的一组细菌进行了比较。 ,处理,存储和分发人体组织。我们能够鉴定出至少两种不同的制剂,这些制剂能够在4 A摄氏度的长时间孵育过程中杀死大多数细菌。

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