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首页> 外文期刊>Cell and tissue banking: An international journal of banking, engineering & transplantation of cells and tissues >Endoscopic versus transcranial procurement of allograft tympano-ossicular systems: a prospective double-blind randomized controlled audit
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Endoscopic versus transcranial procurement of allograft tympano-ossicular systems: a prospective double-blind randomized controlled audit

机译：内窥镜与经颅采购同种异体鼓膜听骨系统：前瞻性双盲随机对照审计

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摘要

Allograft tympano-ossicular systems (ATOS) have proven their use over many decades in tympanoplasty and reconstruction after resection of cholesteatoma. The transcranial bone plug technique has been used in the past 50 years to procure en bloc ATOS (tympanic membrane with malleus, incus and stapes attached). Recently, our group reported the feasibility of the endoscopic procurement technique. The aim of this study was to assess whether clinical outcome is equivalent in ATOS acquired by using the endoscopic procurement technique compared to ATOS acquired by using the transcranial technique. A double-blind randomized controlled audit was performed in a tertiary referral center in patients that underwent allograft tympanoplasty because of chronic otitis media with and without cholesteatoma. Allograft epithelialisation was evaluated at the short-term postoperative visit by microscopic examination. Failures were reported if reperforation was observed. Fifty patients underwent allograft tympanoplasty: 34 received endoscopically procured ATOS and 16 received transcranially procured ATOS. One failed case was observed, in the endoscopic procurement group. We did not observe a statistically significant difference between the two groups in failure rate. This study demonstrates equivalence of the clinical outcome of allograft tympanoplasty using either endoscopic or transcranial procured ATOS and therefore indicates that the endoscopic technique can be considered the new standard procurement technique. Especially because the endoscopic procurement technique has several advantages compared to the former transcranial procurement technique: it avoids risk of prion transmission and it is faster while lacking any noticeable incision.
机译：异体移植鼓膜听骨系统（ATOS）已在胆脂瘤切除术后的鼓室成形术和重建中使用了数十年。在过去的50年中，经颅骨栓塞技术已用于采购整块ATOS（鼓膜，槌骨、,骨和骨）。最近，我们小组报告了内窥镜采购技术的可行性。这项研究的目的是评估与使用经颅技术获得的ATOS相比，使用内窥镜采购技术获得的ATOS的临床结果是否相同。对由于有或无胆脂瘤的慢性中耳炎而接受同种异体鼓膜成形术的患者，在三级转诊中心进行了双盲随机对照检查。术后短期访视通过显微镜检查评估同种异体移植物上皮化。如果观察到穿孔，则报告失败。 50例患者接受了同种异体鼓膜成形术：34例接受内窥镜手术ATOS，16例接受经颅颅手术ATOS。在内窥镜采购组中观察到一个失败的案例。我们没有观察到两组的失效率有统计学差异。这项研究证明了使用内窥镜或经颅手术获得的ATOS进行同种异体鼓膜成形术的临床结果是等效的，因此表明内窥镜技术可以被视为新的标准采购技术。特别是因为与以前的经颅采购技术相比，内窥镜采购技术具有多个优势：它避免了病毒传播的风险，并且速度更快，同时没有明显的切口。

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