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首页> 外文期刊>Cerebral cortex >Morphology and Physiology of Excitatory Neurons in Layer 6b of the Somatosensory Rat Barrel Cortex
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Morphology and Physiology of Excitatory Neurons in Layer 6b of the Somatosensory Rat Barrel Cortex

机译：体感大鼠肾小管皮质6b层兴奋神经元的形态和生理学

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摘要

Neocortical lamina 6B (L6B) is a largely unexplored layer with a very heterogeneous cellular composition. To date, only little is known about L6B neurons on a systematic and quantitative basis. We investigated the morphological and electrophysiological properties of excitatory L6B neurons in the rat somatosensory barrel cortex using whole-cell patch-clamp recordings and simultaneous biocytin fillings. Subsequent histological processing and computer-assisted 3D reconstructions provided the basis for a classification of excitatory L6B neurons according to their structural and functional characteristics. Three distinct clusters of excitatory L6B neurons were identified: (C1) pyramidal neurons with an apical den-drite pointing towards the pial surface, (C2) neurons with a prominent, "apical "-like dendrite not oriented towards the pia, and (C3) multipolar spiny neurons without any preferential dendritic orientation. The second group could be further subdivided into three categories termed inverted, "tangentially" oriented and "horizontally" oriented neurons. Furthermore, based on the axonal domain two subcategories of L6B pyramidal cells were identified that had either a more barrel-column confined or an extended axonal field. The classification of excitatory L6B neurons provided here may serve as a basis for future studies on the structure, function, and synaptic connectivity of L6B neurons.
机译：新皮质薄层6B（L6B）是一个很大程度上未开发的层，具有非常不同的细胞组成。迄今为止，在系统和定量的基础上对L6B神经元知之甚少。我们使用全细胞膜片钳记录和同时生物素填充，调查了大鼠体感桶状皮层中兴奋性L6B神经元的形态和电生理特性。随后的组织学处理和计算机辅助3D重建为根据其结构和功能特征对兴奋性L6B神经元进行分类提供了基础。确定了三个不同的兴奋性L6B神经元簇：（C1）锥体神经元，其顶突指向树枝状表面;（C2）神经元，具有突出的，类似于“顶端”的枝状突起，而不朝向pia;和（C3 ）多极棘突神经元，没有任何优先的树突取向。第二组可以进一步细分为三类，分别称为倒置，“切向”定向和“水平”定向的神经元。此外，基于轴突域，确定了L6B锥体细胞的两个亚类，它们具有更多的桶形柱约束或扩展的轴突场。此处提供的兴奋性L6B神经元的分类可作为将来研究L6B神经元的结构，功能和突触连通性的基础。

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