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首页> 外文期刊>Molecular membrane biology >Dynamic and cellular interactions of nanoparticles in vascular-targeted drug delivery (review).
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Dynamic and cellular interactions of nanoparticles in vascular-targeted drug delivery (review).

机译：纳米粒子在血管靶向药物递送中的动态和细胞相互作用（综述）。

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摘要

Vascular-targeted drug delivery systems could provide more efficient and effective pharmaceutical interventions for treating a variety of diseases including cardiovascular, pulmonary, inflammatory, and malignant disorders. However, several factors must be taken into account when designing these systems. The diverse blood hemodynamics and rheology, and the natural clearance process that tend to decrease the circulation time of foreign particles all lessen the probability of successful carrier interaction with the vascular wall. An effective vascular-targeted drug delivery system must be able to navigate through the bloodstream while avoiding immune clearance, attach to the vascular wall, and release its therapeutic cargo at the intended location. This review will summarize and analyze current literature reporting on (1) nanocarrier fabrication methods and materials that allow for optimum therapeutic encapsulation, protection, and release; (2) localization and binding dynamics of nanocarriers as influenced by hemodynamics and blood rheology in medium-to-large vessels; (3) blood cells' responses to various types of nanocarrier compositions and its effects on particle circulation time; and (4) properties that affect nanocarrier internalization at the target site.
机译：靶向血管的药物输送系统可以提供更有效的药物干预措施，以治疗各种疾病，包括心血管，肺，炎性和恶性疾病。但是，设计这些系统时必须考虑几个因素。血液动力学和流变学的多样性以及自然清除过程会减少异物的循环时间，所有这些都会降低载体与血管壁成功相互作用的可能性。有效的靶向血管的药物输送系统必须能够在血液中导航，同时避免免疫清除，附着在血管壁上并在预定位置释放治疗性药物。这篇综述将总结和分析有关（1）纳米载体制造方法和材料的最新文献报道，这些方法和材料可实现最佳的治疗性封装，保护和释放; （2）受大中型血管的血液动力学和血液流变学影响的纳米载体的定位和结合动力学; （3）血细胞对各种类型的纳米载体成分的反应及其对颗粒循环时间的影响; （4）影响目标部位纳米载体内在化的性质。

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