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首页> 外文期刊>Cardiovascular engineering and technology >Simulated Red Blood Cell Motion in Microvessel Bifurcations: Effects of Cell-Cell Interactions on Celll Partitioning
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Simulated Red Blood Cell Motion in Microvessel Bifurcations: Effects of Cell-Cell Interactions on Celll Partitioning

机译：模拟的微血管分支中的红细胞运动：细胞间相互作用对细胞分区的影响。

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摘要

Partitioning of red blood cell (RBC) fluxes between the branches of a diverging microvessel bifurcation is generally not proportional to the flow rates, as RBCs preferentially enter the higher-flow branch. A two-dimensional model for RBC motion and deformation is used to investigate the effects of cell-cell mechanical interactions on RBC partitioning in bifurcations. The RBC membrane and cytoplasm are represented by sets of viscoelastic elements immersed in a low Reynolds number flow. Several types of two-cell interactions that can affect partitioning are found. In the most frequent interactions, a 'trade-off occurs, in which a cell entering one branch causes a following cell to enter the other branch. Other types of interactions include 'herding,' where the leading cell is caused to enter the same branch as the following cell, and 'following,' where the trailing cell is caused to enter the same branch as the leading cell. The combined effect of these cell-cell interactions is a tendency towards more uniform partitioning, which results from the trade-off effect but is reduced by the herding and following effects. With increasing hemat-ocrit, the frequency of interactions increases, and more uniform partitioning results. This prediction is consistent with experimental observations on how hematocrit affects RBC partitioning.
机译：在发散的微血管分叉的分支之间，红细胞（RBC）通量的分配通常与流速不成比例，因为RBC优先进入流量更高的分支。用于RBC运动和变形的二维模型用于研究分叉中RBC分区的细胞间机械相互作用的影响。 RBC膜和细胞质由浸没在低雷诺数流中的粘弹性元素集表示。发现了几种类型的可影响分区的两单元交互。在最频繁的交互中，发生“折衷”，在这种折衷中，进入一个分支的单元导致下一个单元进入另一个分支。其他类型的交互包括“聚集”（导致前导单元进入与下一个单元格相同的分支）和“跟随”（导致尾随单元进入与前导单元相同的分支）。这些细胞-细胞相互作用的综合作用是趋于更均匀分配的趋势，这是由权衡效应引起的，但由于羊群效应和跟随效应而降低。随着血细胞比容的增加，相互作用的频率增加，并且分配结果更加均匀。该预测与关于血细胞比容如何影响RBC分区的实验观察结果一致。

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