...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cerebral cortex >Age-related Changes in Tissue Signal Properties Within Cortical Areas Important for Word Understanding in 12- to 19-Month-0ld Infants
【24h】

Age-related Changes in Tissue Signal Properties Within Cortical Areas Important for Word Understanding in 12- to 19-Month-0ld Infants

机译：皮质区域内与年龄有关的组织信号特性变化，对理解12-19岁零周岁的1ld婴儿的单词很重要

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Recently, our laboratory has shown that the neural mechanisms for encoding lexico-semantic information in adults operate functionally by 12-18 months of age within left frontotemporal cortices (Travis et al., 2011. Spatiotemporal neural dynamics of word understanding in 12- to 18-month-old-infants. Cereb Cortex. 8:1832-1839). However, there is minimal knowledge of the structural changes that occur within these and other cortical regions important for language development. To identify regional structural changes taking place during this important period in infant development, we examined age-related changes in tissue signal properties of gray matter (GM) and white matter (WM) intensity and contrast, r,-weighted surface-based measures were acquired from 12- to 19-month-old infants and analyzed using a general linear model. Significant age effects were observed for GM and WM intensity and contrast within bilateral inferior lateral and anterovental temporal regions, dorsomedial frontal, and superior parietal cortices. Region of interest (ROI) analyses revealed that GM and WM intensity and contrast significantly increased with age within the same left lateral temporal regions shown to generate lexico-semantic activity in infants and adults. These findings suggest that neurophy-siological processes supporting linguistic and cognitive behaviors may develop before cellular and structural maturation is complete within associative cortices. These results have important implications for understanding the neurobiological mechanisms relating structural to functional brain development.
机译：最近，我们的实验室表明，成年人左词汇语义信息的编码神经机制在左额颞皮层中的功能在12-18个月大时开始起作用（Travis等人，2011年。单词理解的时空神经动力学在12-18岁之间月大婴儿（Cereb Cortex。8：1832-1839）。但是，对这些和其他皮质区域内发生的对语言发展很重要的结构变化的了解很少。为了确定在婴儿发育的这个重要时期发生的区域结构变化，我们检查了与年龄相关的灰质（GM）和白质（WM）强度和对比度的组织信号特性变化，采用基于表面加权的r从12到19个月大的婴儿中采集，并使用一般线性模型进行分析。 GM和WM强度和双侧下外侧和前腹颞区，背侧额叶和顶叶皮层皮质内的对比度方面，观察到了明显的年龄影响。感兴趣区域（ROI）分析显示，在相同的左颞侧颞区域内，GM和WM强度和对比度随着年龄的增长而显着增加，显示出在婴儿和成人中会产生词汇语义活动。这些发现表明，支持语言和认知行为的神经生理学过程可能在缔合皮质内细胞和结构成熟完成之前就已经发展了。这些结果对于理解与功能性大脑发育相关的神经生物学机制具有重要意义。

著录项

相似文献

  • 外文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号