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首页> 外文期刊>Scandinavian journal of clinical and laboratory investigation. >Increased NT-pro-B-type natriuretic peptide independently predicts outcome following catheter ablation of atrial fibrillation.
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Increased NT-pro-B-type natriuretic peptide independently predicts outcome following catheter ablation of atrial fibrillation.

机译：NT-pro-B型利钠尿肽的增加独立地预测了心房纤颤导管消融后的预后。

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AIMS: To investigate whether NT-proBNP before ablation treatment and after exercise testing has predictive information regarding the clinical outcome following pulmonary vein isolation in patients with atrial fibrillation (AF). METHODS: NT-proBNP analysis were obtained before the ablation (before and after exercise test), and repeated at 1, 3, and 12 months after the final procedure. RESULTS: A total of 51 patients were included. At study entry, the median NT-proBNP concentration was 14.0 pmol/L (quartiles: 8.0 and 27.0). After the exercise test, the mean NT-proBNP value increased from 13.0 pmol/L (quartiles: 7.5 and 26.0) to 15.0 pmol/L (quartiles: 9.0 and 34.0), p < 0.001. Following a maximum of two ablations, 22 patients were free of AF while 29 patients experienced recurrent AF. In patients with successful ablation, the mean NT-proBNP concentration at baseline was 10.0 pmol/L (quartiles: 7.0 and 22.2) compared to 22.0 pmol/L (quartiles: 12.0 and 34.5) in patients with ablation failure, p = 0.02. With respect to exercise testing, a trend towards a higher increases during exercise were seen in patients with recurrent AF compared to patients without: 2.0 pmol/L (quartiles 1.9 and 7.0) vs. 1.5 pmol/L (quartiles 0 and 3.0), p = 0.07. A baseline NT-proBNP concentration >15.0 pmol/L was found to be an independent predictor of ablation failure. CONCLUSION: A significantly lower NT-proBNP concentration at baseline and a trend towards a diminished increase during exercise was seen in patients successfully ablated for AF compared to patients with recurrent AF. A baseline NT-proBNP concentration
机译：目的：探讨消融治疗前和运动测试后NT-proBNP是否对房颤患者进行肺静脉隔离后的临床结局具有预测性信息。方法：在消融之前（运动试验前后）进行NT-proBNP分析，并在最终手术后的1、3和12个月重复进行。结果：共纳入51例患者。在研究开始时，NT-proBNP的中位浓度为14.0 pmol / L（四分位数：8.0和27.0）。运动测试后，NT-proBNP的平均值从13.0 pmol / L（四分位数：7.5和26.0）增加到15.0 pmol / L（四分位数：9.0和34.0），p <0.001。最多两次消融后，有22例患者无房颤，而29例患者出现房颤复发。成功消融的患者，基线时NT-proBNP的平均浓度为10.0 pmol / L（四分位数：7.0和22.2），而消融失败的患者为22.0 pmol / L（四分位数：12.0和34.5），p = 0.02。关于运动测试，与没有以下情况的患者相比，复发性房颤患者运动期间有更高的增加趋势：2.0 pmol / L（四分位数1.9和7.0）与1.5 pmol / L（四分位数0和3.0），p = 0.07。发现基线NT-proBNP浓度> 15.0 pmol / L是消融失败的独立预测因子。结论：与复发性AF患者相比，成功消融的AF患者基线时NT-proBNP浓度明显降低，并且运动期间增加趋势趋于减少。 NT-proBNP的基线浓度<或= 15 pmol / l独立预测消融成功。

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