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首页> 外文期刊>Scandinavian journal of clinical and laboratory investigation. >The influence of the gastrointestinal tract and the liver on cystatin C serum concentrations
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The influence of the gastrointestinal tract and the liver on cystatin C serum concentrations

机译：胃肠道和肝脏对胱抑素C血清浓度的影响

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Objective. The purpose of this study in humans was to examine the influence of the gastrointestinal tract and liver on the serum concentrations of cystatin C. Methods. Eighteen healthy volunteers and 28 patients suspected of having chronic intestinal ischemia underwent catheterization of the abdominal aorta and the central hepatic vein. Blood samples were taken simultaneously from the abdominal aorta and the central hepatic vein 60, 90 and 120 minutes after the start of the investigation. After the first blood sample, a standard liquid meal was ingested. Measurement of splanchnic blood flow was performed using the Fick principle with constant infusion of 99mTc-Bridatec?. Angiography was performed at the end of the investigation. Results. The splanchnic blood flow increased significantly postprandially in the healthy volunteers and in the patients with normal angiography by 0.613-0.698 L/min and increased non- significantly in the patients with abnormal angiography (n = 5) by 0.135 L/min on average. ANOVA and the Bonferroni's multiple comparison test showed no significant difference between the means of cystatin C, creatinine or urea in the samples taken 60, 90 and 120 minutes after the start of the investigation in the abdominal aorta and the hepatic vein in the healthy volunteers or in the patients suspected of chronic intestinal ischemia with normal angiography. Conclusion. There was no indication of hepatic elimination of cystatin C, creatinine or urea. The serum concentrations of cystatin C, creatinine and urea in the central hepatic vein and the abdominal aorta were independent of the splanchnic blood flow.
机译：目的。这项研究的目的是研究胃肠道和肝脏对血清胱抑素C浓度的影响。 18名健康志愿者和28名怀疑患有慢性肠缺血的患者接受了腹主动脉和肝中央静脉置管。在研究开始后60、90和120分钟，同时从腹主动脉和肝中央静脉中采集血样。第一次采血后，摄入标准流食。内脏血流量的测量采用Fick原理，并持续输注99mTc-Bridatec?。在研究结束时进行了血管造影。结果。在健康志愿者和正常血管造影患者中，内脏血流量显着增加，餐后增加0.613-0.698 L / min，而在异常血管造影（n = 5）患者中，内脏血流平均增加0.135 L / min。方差分析（ANOVA）和Bonferroni的多重比较试验显示，在开始研究的60、90和120分钟后，健康志愿者或正常人在腹主动脉和肝静脉中采集的样品中，胱抑素C，肌酐或尿素的均值之间无显着差异。血管造影正常的怀疑患有慢性肠缺血的患者。结论。没有迹象表明肝脏清除了胱抑素C，肌酐或尿素。肝中央静脉和腹主动脉中半胱氨酸蛋白酶抑制剂C，肌酐和尿素的浓度与内脏血流无关。

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