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首页> 外文期刊>Scandinavian journal of clinical and laboratory investigation. >First trimester serum levels of the soluble transcobalamin receptor, holo-transcobalamin, and total transcobalamin in relation to preeclampsia risk
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First trimester serum levels of the soluble transcobalamin receptor, holo-transcobalamin, and total transcobalamin in relation to preeclampsia risk

机译：与子痫前期风险相关的可溶性反式钴胺素受体，全反式钴胺素和总反式钴胺素的孕早期血清水平

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Background: Human placenta expresses CD320, a receptor that ensures the uptake of holo-transcobalamin (holoTC). Soluble CD320 (sCD320) is present in the circulation and its concentration increases during pregnancy.Aims: To investigate a possible association of sCD320, holoTC and total transcobalamin (TC) with the risk of subsequent preeclampsia using serum samples from asymptomatic first trimester pregnant women. Moreover, we aimed to establish reference intervals of the aforementioned biomarkers for first trimester pregnant women who remained healthy throughout pregnancy.Study design: This study was a retrospective case-control study that we performed on biobank serum samples. Cases (n=50) and controls (n=198) (matched for gestational age and date of sample collection) were asymptomatic women in early pregnancy [median (range) gestational age=10 (8-12) weeks]. Cases developed preeclampsia while the controls remained normotensive throughout pregnancy. We measured the serum concentration of sCD320, holoTC, and total TC by using in-house ELISA methods.Results: First trimester median concentrations of sCD320, holoTC and total TC were not significantly different between cases and controls. The odd ratio for developing preeclampsia based on exposure to low or high levels of sCD320, holoTC or total TC at first trimester was not significant. The reference intervals (2.5-97.5% percentiles (median)) derived from the controls were 50-170 (90) pmolL for sCD320, 20-140 (70) pmolL for holoTC and 560-1300 (810) pmolL for total TC.Conclusions: The risk of preeclampsia is not predicted by first trimester serum concentrations of sCD320, holoTC or total TC. The first trimester reference intervals for the three parameters is reported.
机译：背景：人胎盘表达CD320，一种确保摄取全反式钴胺素（holoTC）的受体。可溶性CD320（sCD320）存在于循环系统中，其浓度在怀孕期间会增加。目的：使用无症状的早孕孕妇血清样本，研究sCD320，holoTC和总跨钴胺素（TC）与子痫前期风险的可能关系。此外，我们旨在为在整个怀孕期间保持健康的早孕孕妇建立上述生物标志物的参考间隔。研究设计：本研究是一项回顾性病例对照研究，我们对生物库血清样本进行了研究。病例（n = 50）和对照组（n = 198）（与胎龄和样本采集日期相匹配）是怀孕早期无症状的妇女[胎龄（范围（中位数）= 10（8-12）周）]。病例发展为先兆子痫，而对照在整个怀孕期间保持血压正常。我们通过内部ELISA方法测量了sCD320，holoTC和总TC的血清浓度。结果：病例和对照组之间，孕早期的sCD320，holoTC和总TC的中位浓度没有显着差异。基于在孕早期暴露于低或高水平的sCD320，holoTC或总TC导致子痫前期的奇数比率不显着。从对照得出的参考区间（2.5-97.5％百分数（中位数））对于sCD320为50-170（90）pmol L，对于holoTC为20-140（70）pmol L，560-1300（810）pmol 结论：子痫前期的风险不能通过前三个月的sCD320，holoTC或总TC的血清浓度来预测。报告了三个参数的前三个月参考间隔。

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