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首页> 外文期刊>Cerebrovascular diseases >Noninvasive monitoring of cerebral oxygenation during vasomotor reactivity tests by a new near-infrared spectroscopy device.
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Noninvasive monitoring of cerebral oxygenation during vasomotor reactivity tests by a new near-infrared spectroscopy device.

机译：通过新型近红外光谱仪在血管舒缩反应性测试过程中对大脑氧合作用进行无创监测。

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BACKGROUND: Spatially resolved spectroscopy is a recently developed technique for noninvasive monitoring of cerebral tissue oxygenation using the photon diffusion theory. METHODS: We studied this technique with a new, commercial near-infrared spectroscopy (NIRS) device during vasomotor reactivity tests in 28 healthy volunteers (mean age 31.0 years; SD 10.6 years) and compared it with values assessed by the modified Beer-Lambert law and indices from simultaneous transcranial Doppler sonography of both middle cerebral arteries. We measured O(2) reactivity as percentage change of cerebral blood flow velocity (CBFV), as absolute change in the concentrations (measured in micromol/l) of oxygenated (HbO(2)), deoxygenated (Hb) and total hemoglobin (HbT), and as change in the tissue oxygenation index (TOI) during inhalation of 100% oxygen. CO(2) reactivity was calculated as percentage change of CBFV (NCR), as absolute change in the concentrations of HbO(2), Hb, and HbT (micromol/l), and as change in TOI (%) per1% increase in end-tidal CO(2). RESULTS: One hundred percent oxygen inhalation lead to a decrease in CBFV (mean +/- SD: left -8.0 +/- 7.0%, p = 0.000; right -9.6 +/- 7.6%, p = 0.000), an increase in HbO(2) (0.99 +/- 1.07 micromol/l), Hbdiff (2.23 +/- 1.72 micromol/l), and TOI (3.1 +/- 1.5%), and a decrease in Hb (-1.22 +/- 0.74 micromol/l), significant from baseline values (p = 0.0000). CO(2) reactivity was: NCR left 25.4 +/- 14.7%; NCR right 25.9 +/- 13.4%; HbO(2) 1.99 +/- 0.97 micromol/l; Hb -1.24 +/- 0.81 micromol/l; HbT 0.81 +/- 1.0 micromol/l, and TOI 3.7 +/- 2.2%. O(2) reactivity in TCD did not correlate with NIRS reactivities (Pearson p > 0.05), but NCR did correlate with changes in HbO(2), Hb, and TOI (Pearson p < 0.01). TOI was closely related to indices derived from the Beer-Lambert law (Pearson p < 0.03), but not with mean arterial blood pressure or skin blood flow during vasomotor reactivity tests. CONCLUSION: Spatially resolved spectroscopy provides an encouraging, noninvasive new tool to study cerebral tissue oxygenation during vasomotor reactivity tests consistent with physiological changes.
机译：背景：空间分辨光谱学是一种使用光子扩散理论对脑组织氧合进行无创监测的最新技术。方法：我们在28名健康志愿者（平均年龄31.0岁; SD为10.6岁）进行血管舒缩反应性测试期间，使用新型的商用近红外光谱仪（NIRS）对这项技术进行了研究，并将其与修正的Beer-Lambert法评估的值进行了比较和大脑中动脉同时经颅多普勒超声检查的指标。我们将O（2）反应性测量为脑血流速度（CBFV）的百分比变化，作为含氧（HbO（2）），脱氧（Hb）和总血红蛋白（HbT）浓度（以微摩尔/升为单位）的绝对变化），以及吸入100％氧气时组织氧合指数（TOI）的变化。 CO（2）反应性计算为CBFV（NCR）的百分比变化，HbO（2），Hb和HbT（micromol / l）浓度的绝对变化以及TOI（％）每增加1％的变化潮气末CO（2）。结果：百分百的氧气吸入导致CBFV降低（平均+/- SD：左-8.0 +/- 7.0％，p = 0.000;右-9.6 +/- 7.6％，p = 0.000），增加HbO（2）（0.99 +/- 1.07 micromol / l），Hbdiff（2.23 +/- 1.72 micromol / l）和TOI（3.1 +/- 1.5％）和Hb的降低（-1.22 +/- 0.74）相对于基线值（p = 0.0000）显着。 CO（2）反应性是：NCR剩下25.4 +/- 14.7％; NCR正确25.9 +/- 13.4％; HbO（2）1.99 +/- 0.97微摩尔/升; Hb -1.24 +/- 0.81微摩尔/升; HbT 0.81 +/- 1.0微摩尔/升，TOI 3.7 +/- 2.2％。 TCD中的O（2）反应性与NIRS反应性无关（Pearson p> 0.05），但NCR与HbO（2），Hb和TOI的变化相关（Pearson p <0.01）。 TOI与源自Beer-Lambert法则的指数密切相关（Pearson p <0.03），但在血管舒缩反应性测试期间与平均动脉血压或皮肤血流量没有关系。结论：空间分辨光谱学提供了一种令人鼓舞的，非侵入性的新工具，可以在与生理变化相一致的血管舒缩反应性测试期间研究脑组织氧合。

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