Assessing infection risk in implanted tissue-engineered devices.

Kuijer R; Jansen EJ; Emans PJ; Bulstra SK; Riesle J; Pieper J; Grainger DW; Busscher HJ

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Assessing infection risk in implanted tissue-engineered devices.

机译：评估植入的组织工程设备的感染风险。

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Peri-operative contamination is the major cause of biomaterial-associated infections, highly complicating surgical patient outcomes. While this risk in traditional implanted biomaterials is well-recognised, newer cell-seeded, biologically conducive tissue-engineered (TE) constructs now targeted for human use have not been assessed for this possibility. We investigated infection incidence of implanted, degradable polyester TE scaffold biomaterials in rabbit knee osteochondral defects. Sterile, polyester copolymer scaffolds of different compositions and cell-accessible pore volumes were surgically inserted into rabbit osteochondral defects for periods of 3 weeks up to 9 months, either with or without initial seeding with autologous or allogeneic chondrocytes. Infection assessment included observation of pus or abscesses in or near the knee joint and post-mortem histological evaluation. Of 228 implanted TE scaffolds, 10 appeared to be infected: 6 scaffolds without cell seeding (3.6%) and 4 cell-seeded scaffolds (6.3%). These infections were evident across all scaffold types, independent of polymer composition or available pore volume, and up to 9 months. We conclude that infections in TE implants pose a serious problem with incidences similar to current biomaterials-associated infections. Infection control measures should be developed in tissue engineering to avoid further complications when TE devices emerge clinically.

机译：围手术期污染是生物材料相关感染的主要原因，这使外科手术患者的预后高度复杂化。尽管公认的传统植入生物材料存在这种风险，但尚未针对这种可能性评估目前针对人类使用的新型细胞播种，生物有益组织工程（TE）构建体。我们调查了可植入的可降解聚酯TE支架生物材料在兔膝骨软骨缺损中的感染发生率。将具有不同组成和细胞可及孔体积的无菌聚酯共聚物支架通过外科手术插入兔骨软骨缺损中，持续3周至9个月，无论是否接种自体或同种异体软骨细胞。感染评估包括观察膝关节内或附近的脓或脓肿以及验尸组织学评估。在228个植入的TE支架中，有10个似乎被感染：6个没有细胞接种的支架（3.6％）和4个有细胞接种的支架（6.3％）。这些感染在所有类型的支架上都是明显的，独立于聚合物组成或可用的孔体积，长达9个月。我们得出的结论是，TE植入物中的感染与当前与生物材料相关的感染相似，构成了严重的问题。在组织工程中应制定感染控制措施，以避免在临床上出现TE设备时进一步的并发症。

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《Biomaterials》 |2007年第34期|共7页
作者
Kuijer R; Jansen EJ; Emans PJ; Bulstra SK; Riesle J; Pieper J; Grainger DW; Busscher HJ;
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正文语种 eng
中图分类医用一般科学;
关键词
Tellurium; Infection as complication of medical care; Cells; device aspects; 碲; 细胞; 组织;

机译：Tellurium;Infection as complication of medical care;Cells;device aspects;碲;细胞;组织;

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Assessing infection risk in implanted tissue-engineered devices.

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