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首页> 外文期刊>Scandinavian journal of gastroenterology. >Autoimmune liver disease in patients with systemic lupus erythematosus: a retrospective analysis of 147 cases.
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Autoimmune liver disease in patients with systemic lupus erythematosus: a retrospective analysis of 147 cases.

机译：系统性红斑狼疮患者的自身免疫性肝病：147例回顾性分析。

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OBJECTIVE: We aimed to investigate the characteristics of autoimmune liver disease (AILD) developed in patients with systemic lupus erythematosus (SLE), including autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC) and the AIH/PBC overlap syndrome. We also evaluated the accuracy of diagnostic criteria and scoring systems for AILD in SLE. METHODS: A retrospective analysis of patients attending the rheumatology and gastroenterology clinics in Ankara, Turkey, between 1999 and 2010. SLE patients with elevated liver enzymes were investigated for liver diseases. RESULTS: A total of 147 SLE patients were identified and 36 of them had liver enzyme abnormalities. AILD was diagnosed in 4.7% of all SLE patients, in 19.4% of those with elevated liver enzymes. Of patients with liver enzyme abnormalities, 72.3% fulfilled the criteria for AIH proposed by the International Autoimmune Hepatitis Group (IAIHG), whereas 66.7% had AIH by using the simplified criteria. Yet, only 13.8% of these patients had liver biopsy findings consistent with AIH. Patients with AILD were treated with conventional therapy including ursodeoxycholic acid, prednisolone, azathioprine or combinations of these. Treatment failure and subsequent advanced liver disease developed in one patient. CONCLUSIONS: AILD may occur during the course of SLE. Due to biochemical similarities between AIH and SLE, AIH could be considered very probable by using both IAIHG scoring system and simplified criteria. For definitive diagnosis of AIH, liver biopsy should be performed in all SLE patients with chronic enzyme abnormalities. The response to therapy is favorable in these patients, and early diagnosis is important for preventing advanced liver disease.
机译：目的：我们研究系统性红斑狼疮（SLE）患者的自身免疫性肝病（AILD）的特征，包括自身免疫性肝炎（AIH），原发性胆汁性肝硬化（PBC）和AIH / PBC重叠综合征。我们还评估了SLE中AILD的诊断标准和评分系统的准确性。方法：回顾性分析1999年至2010年在土耳其安卡拉风湿病和肠胃病诊所就诊的患者。对肝病患者肝酶升高的SLE患者进行了调查。结果：共鉴定出147例SLE患者，其中36例具有肝酶异常。在所有SLE患者中，有4.7％诊断为AILD，在肝酶升高的患者中诊断为AID的占19.4％。在肝酶异常患者中，有72.3％符合国际自身免疫性肝炎小组（IAIHG）提出的AIH标准，而使用简化标准则有66.7％患有AIH。然而，这些患者中只有13.8％的肝脏活检结果与AIH一致。 AILD患者接受常规治疗，包括熊去氧胆酸，泼尼松龙，硫唑嘌呤或这些药物的组合。一名患者发生了治疗失败和随后的晚期肝病。结论：SLE过程中可能发生AILD。由于AIH和SLE之间的生化相似性，通过使用IAIHG评分系统和简化的标准，可以认为AIH非常可能。为了明确诊断AIH，应对所有患有慢性酶异常的SLE患者进行肝活检。这些患者对治疗的反应良好，并且早期诊断对于预防晚期肝病很重要。

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