Calcineurin phosphatase activity and immunosuppression. A review on the role of calcineurin phosphatase activity and the immunosuppressive effect of cyclosporin A and tacrolimus.

Jorgensen KA; Koefoed Nielsen PB; Karamperis N

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Calcineurin phosphatase activity and immunosuppression. A review on the role of calcineurin phosphatase activity and the immunosuppressive effect of cyclosporin A and tacrolimus.

机译：钙调神经磷酸酶活性和免疫抑制。钙调神经磷酸酶活性的作用以及环孢菌素A和他克莫司的免疫抑制作用的综述。

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The mode of immunosuppressive action of tacrolimus (FK506) and cyclosporin A has been elucidated. Both drugs bind to proteins in the cytoplasm to form complexes, which in turn inhibit the phosphatase activity of calcineurin, an important limiting step in the activation of T cells. The association between drug uptake (pharmacokinetics) and enzyme inhibition (pharmacodynamics) is under current investigation. Great variations in the correlation between blood drug levels and enzyme inhibition could indicate that monitoring calcineurin phosphatase activity for treatment might be superior to monitoring blood drug levels.

机译：他克莫司（FK506）和环孢菌素A的免疫抑制作用的模式已经阐明。两种药物都与细胞质中的蛋白质结合形成复合物，从而抑制钙调神经磷酸酶的磷酸酶活性，这是T细胞活化的重要限制步骤。目前正在研究药物吸收（药代动力学）和酶抑制（药代动力学）之间的关系。血液药物水平与酶抑制之间的相关性差异很大，这表明监测钙调神经磷酸酶活性的治疗可能优于监测血液药物水平。

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《Scandinavian journal of immunology.》 |2003年第2期|共6页
作者
Jorgensen KA; Koefoed Nielsen PB; Karamperis N;
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正文语种 eng
中图分类医学免疫学;
关键词
Tacrolimus; 他罗利姆;

机译：Tacrolimus;他罗利姆;

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1. Calcineurin phosphatase activity and immunosuppression. A review on the role of calcineurin phosphatase activity and the immunosuppressive effect of cyclosporin A and tacrolimus. [J] . Jorgensen KA, Koefoed Nielsen PB, Karamperis N Scandinavian journal of immunology. . 2003,第2期

机译：钙调神经磷酸酶活性和免疫抑制。钙调神经磷酸酶活性的作用以及环孢菌素A和他克莫司的免疫抑制作用的综述。
2. Distinct Inhibitory Effects of Tacrolimus and Cyclosporin A on Calcineurin Phosphatase Activity [J] . Masahide Fukudo, Ikuko Yano, Satohiro Masuda, The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2005,第2期

机译：他克莫司和环孢菌素A对钙调磷酸酶磷酸酶活性的不同抑制作用。
3. Calcineurin phosphatase activity: activation by glucocorticoids and role of intracellular calcium. [J] . Tong DC, Buck SM, Roberts BR, Transplantation: Official Journal of the Transplantation Society . 2004,第2期

机译：钙调神经磷酸酶活性：被糖皮质激素激活和细胞内钙的作用。
4. A NEW APPROACH TO ASSAY THE ENZYMATIC ACTIVITY OF CALCINEURIN AND THE INHIBITORY EFFECT OF ZINC ION [C] . Genxi LI, Dongmei ZHANG, Wei XING, The 12th International Beijing Conference and Exhibition on Instrumental Analysis : Conference Abstracts . 2007

机译：测定钙离子酶活性和锌离子抑制作用的一种新方法。
5. The pathological role of alterations in calcineurin (protein phosphatase 2B) phosphatase activity in Alzheimer's disease. [D] . Lian, Qingyu. 2002

机译：钙调神经磷酸酶（蛋白磷酸酶2B）磷酸酶活性改变在阿尔茨海默氏病中的病理学作用。
6. Inhibiting the Calcineurin-NFAT (Nuclear Factor of Activated T Cells) Signaling Pathway with a Regulator of Calcineurin-derived Peptide without Affecting General Calcineurin Phosphatase Activity [O] . M, Carme Mulero, Anna Aubareda, 2009

机译：抑制钙调神经磷酸酶-NFAT（活化的T细胞的核因子）不含钙调神经磷酸肽的调节因子的信号通路影响一般钙调磷酸酶磷酸酶活动
7. Inhibiting the calcineurin-NFAT (nuclear factor of activated T cells) signaling pathway with a regulator of calcineurin-derived peptide without affecting general calcineurin phosphatase activity [O] . Mulero, M. Carmen, Aubareda, Anna, Orzáez, Mar, 2009

机译：用钙调磷酸酶衍生肽的调节剂抑制钙调磷酸酶-NFAT（活化的T细胞的核因子）信号传导途径，而不影响钙调磷酸酶磷酸酶的一般活性

Calcineurin phosphatase activity and immunosuppression. A review on the role of calcineurin phosphatase activity and the immunosuppressive effect of cyclosporin A and tacrolimus.

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