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首页> 外文期刊>Scandinavian journal of immunology. >The role of t-regulatory cells and toll-like receptors 2 and 4 in atopic dermatitis
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The role of t-regulatory cells and toll-like receptors 2 and 4 in atopic dermatitis

机译：T调节细胞和Toll样受体2和4在特应性皮炎中的作用

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Regulatory T cells (Tregs), toll-like receptors (TLRs) and interleukin-17 (IL-17) play important role in inflammatory diseases; however, their relevance in atopic dermatitis (AD) pathogenesis is not clear. The aim of study was to evaluate the number of circulating Tregs and peripheral blood mononuclear cells (PBMC) expressing TLR2 and TLR4 receptors in patients with AD. PBMC and CD4+/CD25 high+ Tregs were isolated from the whole blood of 32 AD patients and 36 healthy volunteers. Expression of CD4+CD25+, TLR2 and TLR4 receptors and IL 17+ was assessed with the flow cytometry. In the peripheral blood of AD patients, the percentage of Tregs was significantly higher when compared with the controls (P=0.0003). The number of TLR2+PBMC and TLR4+ PBMC in AD patients was significantly lower than in the controls (P=0.035; P=0.001, respectively). Also the percentages of Tregs with expression of both TLR2+ and TLR4+ in AD patients were significantly lower than in the control (3.85 versus 21.6, P0.0001; 2.2 versus 17.6, P0.0001, simultaneously). The percentage of CD4+/CD25high+/FOXP3+ Treg lymphocytes with expression of IL-17 was significantly higher in AD group than in healthy subjects (0.3% versus 0.06%; P=0.011). Distinct number of Tregs and various distribution of TLR2 and TLR4 expression on PBMC in AD patients suggest their contribution in the pathogenesis of AD.
机译：调节性T细胞（Tregs），toll​​样受体（TLRs）和白介素17（IL-17）在炎性疾病中起重要作用。然而，它们在特应性皮炎（AD）发病机理中的相关性尚不清楚。研究的目的是评估AD患者中表达TLR2和TLR4受体的循环Treg和外周血单核细胞（PBMC）的数量。从32位AD患者和36位健康志愿者的全血中分离出PBMC和CD4 + / CD25 high + Treg。用流式细胞术评估CD4 + CD25 +，TLR2和TLR4受体以及IL 17+的表达。在AD患者的外周血中，与对照组相比，Tregs的百分比显着更高（P = 0.0003）。 AD患者中TLR2 + PBMC和TLR4 + PBMC的数量显着低于对照组（分别为P = 0.035; P = 0.001）。同样，AD患者中同时具有TLR2 +和TLR4 +表达的Tregs的百分比显着低于对照组（分别为3.85对21.6，P <0.0001; 2.2对17.6，P <0.0001）。 AD组中具有IL-17表达的CD4 + / CD25high + / FOXP3 + Treg淋巴细胞百分比显着高于健康受试者（0.3％对0.06％; P = 0.011）。 AD患者PBMC中Treg的不同数目以及TLR2和TLR4表达的各种分布表明它们在AD的发病机理中起作用。

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