...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Scandinavian journal of infectious diseases. >Correlation between BCG genomics and protective efficacy.
【24h】

Correlation between BCG genomics and protective efficacy.

机译：BCG基因组学与保护功效之间的相关性。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Between the derivation of bacille Calmette-Guerin (BCG) vaccine in 1921 and the lyophilization of BCG daughter strains in the 1960s, a number of clinical trials were performed looking at the protective efficacy of BCG vaccination against tuberculosis. These trials differed from one another in a number of ways: they employed different methodologies for delivering the vaccine and interpreting outcomes; they were performed on populations with different genetic backgrounds and different levels of exposure to environmental Mycobacteria; and, finally, they used different BCG vaccine strains. The results of these trials were estimates of protective efficacy against pulmonary tuberculosis ranging from about 80% to nil. Because of the differences in outcomes and confounding variables, it is difficult to conclude whether differences in interventions alone may have contributed to the remarkably variable results. Analysis of BCG vaccines used in clinical trials suggests a trend towards decreasing efficacy with increased passage in the laboratory; however, trials that used relatively "older" BCG strains were generally performed at different sites than trials which used "younger" BCG strains. Genomic analysis of BCG vaccines demonstrates that during the half-century of ongoing passage of BCG vaccines in vitro there have been numerous genetic changes, comprising single nucleotide polymorphisms, duplications and deletions. The impact of these changes in the BCG genome on the protective efficacy observed in field trials remains to be determined.
机译：在1921年推出卡介苗疫苗（BCG）疫苗和1960年代BCG子代菌株冻干之间，进行了许多临床试验，研究了BCG疫苗接种对结核病的保护作用。这些试验在许多方面彼此不同：它们采用了不同的方法来提供疫苗和解释结果。它们是在具有不同遗传背景和环境分枝杆菌暴露水平的人群中进行的;最后，他们使用了不同的BCG疫苗株。这些试验的结果是估计对肺结核的保护功效约为80％至零。由于结果和变量混淆的差异，很难断定仅干预措施的差异是否可能对明显变化的结果有所贡献。对临床试验中使用的BCG疫苗的分析表明，随着在实验室中传代的增加，功效逐渐降低。但是，与使用“较年轻” BCG菌株的试验相比，使用相对“较老” BCG菌株的试验通常在不同的地点进行。 BCG疫苗的基因组分析表明，在BCG疫苗持续进行体外培养的半个世纪中，发生了许多遗传变化，包括单核苷酸多态性，重复和缺失。 BCG基因组中这些变化对现场试验中观察到的保护功效的影响尚待确定。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号